Target Information

Target General Infomation
Target ID
T35232
Former ID
TTDNC00584
Target Name
Recombinant human interleukin-7
Gene Name
IL7
Synonyms
Interleukin7; IL7
Target Type
Clinical Trial
Disease Multiple scierosis [ICD9: 340; ICD10: G35]
Function
Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.
BioChemical Class
Interleukin receptor family
UniProt ID
P13232
Sequence
MFHVSFRYIFGLPPLILVLLPVASSDCDIEGKDGKQYESVLMVSIDQLLDSMKEIGSNCL
NNEFNFFKRHICDANKEGMFLFRAARKLRQFLKMNSTGDFDLHLLKVSEGTTILLNCTGQ
VKGRKPAALGEAQPTKSLEENKSLKEQKKLNDLCFLKRLLQEIKTCWNKILMGTKEH
Drugs and Mode of Action
Drug(s) GSK2618960 Drug Info Phase 1 Multiple scierosis [524235]
Modulator GSK2618960 Drug Info [525001]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage
NetPath Pathway TNFalpha Signaling Pathway
PANTHER Pathway Interleukin signaling pathway
Reactome Interleukin-7 signaling
WikiPathways Cytokines and Inflammatory Response
Interleukin-7 signaling
IL-7 Signaling Pathway
References
Ref 524235ClinicalTrials.gov (NCT01808482) A First Time in Human Study Exploring Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of GSK2618960 in Healthy Volunteers and Patients With Relapsing Remitting Multiple Sclerosis (RRMS). U.S. National Institutes of Health.
Ref 525001ClinicalTrials.gov (NCT02293161) Single Ascending Doses Study of Anti- Interleukin-7 Receptor alpha Monoclonal Antibody (GSK2618960) in Healthy Volunteers. U.S. National Institutes of Health.

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