Target Information

Target General Infomation
Target ID
T91286
Former ID
TTDNC00499
Target Name
STEAP1
Gene Name
STEAP1
Synonyms
Metalloreductase STEAP1; Sixtransmembrane epithelial antigen of prostate 1; STEAP1
Target Type
Clinical Trial
Disease Prostate cancer [ICD9: 185; ICD10: C61]
Function
Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity).
BioChemical Class
Metal ion oxidoreductase
UniProt ID
Q9UHE8
EC Number
EC 1.16.1.-
Sequence
MESRKDITNQEELWKMKPRRNLEEDDYLHKDTGETSMLKRPVLLHLHQTAHADEFDCPSE
LQHTQELFPQWHLPIKIAAIIASLTFLYTLLREVIHPLATSHQQYFYKIPILVINKVLPM
VSITLLALVYLPGVIAAIVQLHNGTKYKKFPHWLDKWMLTRKQFGLLSFFFAVLHAIYSL
SYPMRRSYRYKLLNWAYQQVQQNKEDAWIEHDVWRMEIYVSLGIVGLAILALLAVTSIPS
VSDSLTWREFHYIQSKLGIVSLLLGTIHALIFAWNKWIDIKQFVWYTPPTFMIAVFLPIV
VLIFKSILFLPCLRKKILKIRHGWEDVTKINKTEICSQL
Drugs and Mode of Action
Drug(s) RG7450 Drug Info Phase 1 Prostate cancer [549222]
Modulator RG7450 Drug Info [544371]
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Mineral absorption
WikiPathways Copper homeostasis
References
Ref 549222Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033873)
Ref 544371Marine-Sourced Anti-Cancer and Cancer Pain Control Agents in Clinical and Late Preclinical Development. Mar Drugs. 2014 January; 12(1): 255-278.

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