Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T30790
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| Former ID |
TTDC00342
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| Target Name |
Calcium-release activated calcium channel
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| Gene Name |
ORAI1
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| Synonyms |
Calcium release-activated calcium channel protein 1; Protein orai-1; Transmembrane protein 142A; ORAI1
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| Target Type |
Research
|
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| Function |
Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.
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| BioChemical Class |
Ca(2+) release-activated ca(2+) channel
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| UniProt ID | |||||
| Sequence |
MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSY
SEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLL IAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFST VIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIAST TIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHY A |
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| Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
| TEP | EXP Info | ||||
| Pathways | |||||
| KEGG Pathway | Calcium signaling pathway | ||||
| cAMP signaling pathway | |||||
| Platelet activation | |||||
| Primary immunodeficiency | |||||
| Pathway Interaction Database | TCR signaling in na& | ||||
| #xef | |||||
| ve CD4+ T cells | |||||
| TCR signaling in na& | |||||
| ve CD8+ T cells | |||||
| Reactome | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | ||||
| WikiPathways | Signaling by the B Cell Receptor (BCR) | ||||
| Platelet homeostasis | |||||
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