Drug Information
| Drug General Information | |||||
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| Drug ID |
DXD7HS
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| Drug Name |
(2E)-4-(dimethylamino)-N-[7-ethoxy-4-({4-[(3-methoxybenzyl)oxy]-3,6-dioxocyclohexa-1,4-dien-1-yl}amino)-quinazolin-6-yl]but-2-enamide
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| Synonyms |
CHEMBL241918
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C30H31N5O6
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| Canonical SMILES |
CCOc1cc2ncnc(NC3=CC(=O)C(=CC3=O)OCc4cccc(OC)c4)c2cc1NC(=O)\\C=C\\CN(C)C
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| InChI |
InChI=1S/C30H31N5O6/c1-5-40-27-15-22-21(13-24(27)33-29(38)10-7-11-35(2)3)30(32-18-31-22)34-23-14-26(37)28(16-25(23)36)41-17-19-8-6-9-20(12-19)39-4/h6-10,12-16,18H,5,11,17H2,1-4H3,(H,33,38)(H,31,32,34)/b10-7+
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| InChIKey |
SULRERSGIWVFEH-JXMROGBWSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Epidermal growth factor receptor III | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathway | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY network | |||||
| References | |||||
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