Drug Information
| Drug General Information | |||||
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| Drug ID |
DXR19B
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| Drug Name |
(3R,5S)-5-((4-(3-chloro-4-(6-fluoroquinolin-4-yloxy)phenylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl morpholine-4-carboxylate
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| Synonyms |
CHEMBL505463
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C32H26ClFN6O4S
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| Canonical SMILES |
Fc1ccc2nccc(Oc3ccc(Nc4ncnc5cc(C#C[C@@H]6C[C@H](CN6)OC(=O)N7CCOCC7)sc45)cc3Cl)c2c1
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| InChI |
InChI=1S/C32H26ClFN6O4S/c33-25-15-21(3-6-29(25)44-28-7-8-35-26-5-1-19(34)13-24(26)28)39-31-30-27(37-18-38-31)16-23(45-30)4-2-20-14-22(17-36-20)43-32(41)40-9-11-42-12-10-40/h1,3,5-8,13,15-16,18,20,22,36H,9-12,14,17H2,(H,37,38,39)/t20-,22-/m1/s1
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| InChIKey |
FCKGEOQXHWZJHO-IFMALSPDSA-N
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| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
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