| Drug General Information |
| Drug ID |
DXWQ0S
|
| Drug Name |
(4-Chloro-phenyl)-(4-pyrimidin-4-ylmethyl-phthalazin-1-yl)-amine
|
| Synonyms |
CHEMBL419458
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Formula |
C19H14ClN5
|
| Canonical SMILES |
Clc1ccc(Nc2nnc(Cc3ccncn3)c4ccccc24)cc1
|
| InChI |
InChI=1S/C19H14ClN5/c20-13-5-7-14(8-6-13)23-19-17-4-2-1-3-16(17)18(24-25-19)11-15-9-10-21-12-22-15/h1-10,12H,11H2,(H,23,25)
|
| InChIKey |
QGCUYXCPMZGMFQ-UHFFFAOYSA-N
|
| Target and Pathway |
| Target(s) |
Vascular endothelial growth factor receptor 2 |
Target Info |
|
[1]
|
|---|
| Vascular endothelial growth factor receptor 1 |
Target Info |
|
[1]
|
|
KEGG Pathway
|
Ras signaling pathway
|
|
Rap1 signaling pathway
|
|
Cytokine-cytokine receptor interaction
|
|
Endocytosis
|
|
PI3K-Akt signaling pathway
|
|
VEGF signaling pathway
|
|
Focal adhesion
|
|
Proteoglycans in cancerhsa04014:Ras signaling pathway
|
|
HIF-1 signaling pathway
|
|
Transcriptional misregulation in cancer
|
|
Rheumatoid arthritis
|
|
NetPath Pathway
|
IL2 Signaling Pathway
|
|
PANTHER Pathway
|
Angiogenesis
|
|
VEGF signaling pathway
|
|
Pathway Interaction Database
|
HIF-2-alpha transcription factor network
|
|
Beta3 integrin cell surface interactions
|
|
Signaling events mediated by TCPTP
|
|
SHP2 signaling
|
|
S1P1 pathway
|
|
VEGF and VEGFR signaling network
|
|
Integrins in angiogenesis
|
|
Signaling events mediated by VEGFR1 and VEGFR2
|
|
Notch-mediated HES/HEY networkglypican_1pathway:Glypican 1 network
|
|
S1P3 pathway
|
|
VEGFR1 specific signals
|
|
Reactome
|
Neurophilin interactions with VEGF and VEGFR
|
|
VEGF binds to VEGFR leading to receptor dimerization
|
|
Integrin cell surface interactions
|
|
EPHA-mediated growth cone collapse
|
|
VEGFA-VEGFR2 Pathway
|
|
VEGFR2 mediated cell proliferationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
|
|
WikiPathways
|
Focal Adhesion
|
|
Nifedipine Activity
|
|
Cardiac Progenitor Differentiation
|
|
Signaling by VEGF
|
|
AngiogenesisWP306:Focal Adhesion
|
|
Angiogenesis
|
| References |
| REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 |
|---|
