Drug Information

Drug General Information
Drug ID
DX2C3N
Drug Name
(E/Z)-6-(2-(6-phenylimidazo[2,1-b]thiazol-5-yl)vinyl)pyrimidin-4-amine
Synonyms
CHEMBL502543
Indication Discovery agent Investigative [1587926]
Formula
C17H13N5S
Canonical SMILES
Nc1cc(\\C=C\\c2c(nc3sccn23)c4ccccc4)ncn1
InChI
InChI=1S/C17H13N5S/c18-15-10-13(19-11-20-15)6-7-14-16(12-4-2-1-3-5-12)21-17-22(14)8-9-23-17/h1-11H,(H2,18,19,20)/b7-6+
InChIKey
FIZQADVSPVFTQI-VOTSOKGWSA-N
Target and Pathway
Target(s) Vascular endothelial growth factor receptor 1 Target Info [1587926]
Angiopoietin 1 receptor Target Info [1587926]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Focal adhesion
Transcriptional misregulation in cancer
Rheumatoid arthritishsa04014:Ras signaling pathway
Rheumatoid arthritis
NetPath Pathway Wnt Signaling Pathway
PANTHER Pathway Angiogenesis
Pathway Interaction Database Glypican 1 network
HIF-2-alpha transcription factor network
S1P3 pathway
VEGF and VEGFR signaling network
VEGFR1 specific signals
Signaling events mediated by VEGFR1 and VEGFR2angiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling
SHP2 signaling
Reactome Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerizationR-HSA-210993:Tie2 Signaling
RAF/MAP kinase cascade
WikiPathways Focal Adhesion
Signaling by VEGF
AngiogenesisWP363:Wnt Signaling Pathway Netpath
Cell surface interactions at the vascular wall
Angiogenesis
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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