Drug Information

Drug General Information
Drug ID
DX0EZ1
Drug Name
(S)-6-(Benzenecarbonylamino)-7-(biphenyl-3-ylamino)-7-oxoheptylboronic acid
Synonyms
CHEMBL491130
Indication Discovery agent Investigative [1587926]
Formula
C26H29BN2O4
Canonical SMILES
OB(O)CCCCC[C@H](NC(=O)c1ccccc1)C(=O)Nc2cccc(c2)c3ccccc3
InChI
InChI=1S/C26H29BN2O4/c30-25(21-13-6-2-7-14-21)29-24(17-8-3-9-18-27(32)33)26(31)28-23-16-10-15-22(19-23)20-11-4-1-5-12-20/h1-2,4-7,10-16,19,24,32-33H,3,8-9,17-18H2,(H,28,31)(H,29,30)/t24-/m0/s1
InChIKey
QCMOMEOGDAWUFS-DEOSSOPVSA-N
Target and Pathway
Target(s) Histone deacetylase 6 Target Info [1587926]
Histone deacetylase 2 Target Info [1587926]
KEGG Pathway Alcoholism
Viral carcinogenesishsa04110:Cell cycle
Notch signaling pathway
Thyroid hormone signaling pathway
Huntington's disease
Epstein-Barr virus infection
Pathways in cancer
Transcriptional misregulation in cancer
Viral carcinogenesis
Chronic myeloid leukemia
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Wnt signaling pathway
Pathway Interaction Database Signaling events mediated by HDAC Class II
Signaling events mediated by HDAC Class Ismad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class I
Regulation of Telomerase
Glucocorticoid receptor regulatory network
Direct p53 effectors
Hedgehog signaling events mediated by Gli proteins
Regulation of nuclear beta catenin signaling and target gene transcription
Reactome NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Assembly of the primary ciliumR-HSA-193670:p75NTR negatively regulates cell cycle via SC1
HDACs deacetylate histones
NoRC negatively regulates rRNA expression
RNA Polymerase I Transcription Initiation
Factors involved in megakaryocyte development and platelet production
WikiPathways Ectoderm Differentiation
Neural Crest Differentiation
Cell CycleWP61:Notch Signaling Pathway
Notch Signaling Pathway
Signalling by NGF
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Factors involved in megakaryocyte development and platelet production
Cell Cycle
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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