Drug General Information |
Drug ID |
DX8TTS
|
Drug Name |
(S)-N*1*-(6-Naphthalen-1-yl-5-pyridin-4-yl-pyridazin-3-yl)-3-phenyl-propane-1,2-diamine
|
Synonyms |
CHEMBL436291
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Formula |
C28H25N5
|
Canonical SMILES |
N[C@H](CNc1cc(c2ccncc2)c(nn1)c3cccc4ccccc34)Cc5ccccc5
|
InChI |
InChI=1S/C28H25N5/c29-23(17-20-7-2-1-3-8-20)19-31-27-18-26(22-13-15-30-16-14-22)28(33-32-27)25-12-6-10-21-9-4-5-11-24(21)25/h1-16,18,23H,17,19,29H2,(H,31,32)/t23-/m0/s1
|
InChIKey |
GRGBIILCNWAXOF-QHCPKHFHSA-N
|
Target and Pathway |
Target(s) |
Mitogen-activated protein kinase 10 |
Target Info |
|
[1]
|
MAP kinase p38 |
Target Info |
|
[1]
|
KEGG Pathway
|
MAPK signaling pathway
|
ErbB signaling pathway
|
Ras signaling pathway
|
cAMP signaling pathway
|
FoxO signaling pathway
|
Sphingolipid signaling pathway
|
Protein processing in endoplasmic reticulum
|
Wnt signaling pathway
|
Osteoclast differentiation
|
Focal adhesion
|
Toll-like receptor signaling pathway
|
NOD-like receptor signaling pathway
|
RIG-I-like receptor signaling pathway
|
Fc epsilon RI signaling pathway
|
TNF signaling pathway
|
Neurotrophin signaling pathway
|
Retrograde endocannabinoid signaling
|
Dopaminergic synapse
|
Inflammatory mediator regulation of TRP channels
|
Insulin signaling pathway
|
GnRH signaling pathway
|
Progesterone-mediated oocyte maturation
|
Prolactin signaling pathway
|
Adipocytokine signaling pathway
|
Type II diabetes mellitus
|
Non-alcoholic fatty liver disease (NAFLD)
|
Epithelial cell signaling in Helicobacter pylori infection
|
Shigellosis
|
Salmonella infection
|
Pertussis
|
Chagas disease (American trypanosomiasis)
|
Toxoplasmosis
|
Tuberculosis
|
Hepatitis C
|
Hepatitis B
|
Influenza A
|
Herpes simplex infection
|
Epstein-Barr virus infection
|
Pathways in cancer
|
Colorectal cancer
|
Pancreatic cancer
|
Choline metabolism in cancerhsa04010:MAPK signaling pathway
|
Rap1 signaling pathway
|
Oocyte meiosis
|
Adrenergic signaling in cardiomyocytes
|
VEGF signaling pathway
|
Signaling pathways regulating pluripotency of stem cells
|
Platelet activation
|
T cell receptor signaling pathway
|
Leukocyte transendothelial migration
|
Amyotrophic lateral sclerosis (ALS)
|
Leishmaniasis
|
Proteoglycans in cancer
|
NetPath Pathway
|
TCR Signaling Pathway
|
PANTHER Pathway
|
Alzheimer disease-amyloid secretase pathway
|
Apoptosis signaling pathway
|
B cell activation
|
EGF receptor signaling pathway
|
FAS signaling pathway
|
FGF signaling pathway
|
Integrin signalling pathway
|
Interferon-gamma signaling pathway
|
Parkinson disease
|
TGF-beta signaling pathway
|
Ras Pathway
|
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
|
Oxidative stress response
|
p53 pathway feedback loops 2
|
p38 MAPK pathway
|
Pathway Interaction Database
|
Noncanonical Wnt signaling pathway
|
CD40/CD40L signaling
|
FAS (CD95) signaling pathway
|
Glucocorticoid receptor regulatory network
|
FoxO family signaling
|
p75(NTR)-mediated signaling
|
ErbB2/ErbB3 signaling events
|
PDGFR-beta signaling pathway
|
Nephrin/Neph1 signaling in the kidney podocyterhoa_pathway:RhoA signaling pathway
|
Signaling mediated by p38-gamma and p38-delta
|
Reactome
|
Oxidative Stress Induced Senescence
|
FCERI mediated MAPK activation
|
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
|
Activation of the AP-1 family of transcription factorsR-HSA-168638:NOD1/2 Signaling Pathway
|
p38MAPK events
|
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
|
CDO in myogenesis
|
DSCAM interactions
|
VEGFA-VEGFR2 Pathway
|
WikiPathways
|
Toll-like receptor signaling pathway
|
DNA Damage Response (only ATM dependent)
|
G13 Signaling Pathway
|
Insulin Signaling
|
Wnt Signaling Pathway
|
MAPK Cascade
|
Oxidative Stress
|
Wnt Signaling Pathway and Pluripotency
|
Apoptosis Modulation by HSP70
|
MAPK Signaling Pathway
|
Nanoparticle-mediated activation of receptor signaling
|
Structural Pathway of Interleukin 1 (IL-1)
|
Apoptosis
|
BDNF signaling pathway
|
Integrin-mediated Cell Adhesion
|
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
|
Signal Transduction of S1P Receptor
|
Parkinsons Disease Pathway
|
miR-targeted genes in muscle cell - TarBase
|
miR-targeted genes in lymphocytes - TarBase
|
NGF signalling via TRKA from the plasma membrane
|
Myogenesis
|
DSCAM interactions
|
Regulation of toll-like receptor signaling pathway
|
References |
REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 |