Drug Information

Drug General Information
Drug ID
DX5MUX
Drug Name
(Z)-3-({3-[3-(Diethylamino)propyl]-4-oxo-4,5,6,7-tetrahydro-1H-indol-2-yl}methylene)-5-(indolin-1-ylsulfonyl)indolin-2-one
Synonyms
CHEMBL1215349
Indication Discovery agent Investigative [1587926]
Formula
C32H36N4O4S
Canonical SMILES
CCN(CC)CCCc1c(\\C=C\\2/C(=O)Nc3ccc(cc23)S(=O)(=O)N4CCc5ccccc45)[nH]c6CCCC(=O)c16
InChI
InChI=1S/C32H36N4O4S/c1-3-35(4-2)17-8-10-23-28(33-27-11-7-13-30(37)31(23)27)20-25-24-19-22(14-15-26(24)34-32(25)38)41(39,40)36-18-16-21-9-5-6-12-29(21)36/h5-6,9,12,14-15,19-20,33H,3-4,7-8,10-11,13,16-18H2,1-2H3,(H,34,38)/b25-20-
InChIKey
HZGUNBBYCUIOFD-QQTULTPQSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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