Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX7OSG
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| Drug Name |
[1-[2-(2,4-Dichloro-phenyl)-ethylcarbamoyl]-2-(1H-indol-3-yl)-1-methyl-ethyl]-carbamic acid adamantan-2-yl ester
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| Synonyms |
CHEMBL319120
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| Indication | Discovery agent | Investigative | [1] | ||
| Formula |
C31H35Cl2N3O3
|
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| Canonical SMILES |
CC(Cc1c[nH]c2ccccc12)(NC(=O)OC3[C@@H]4C[C@H]5C[C@H](C[C@@H]3C5)C4)C(=O)NCCc6ccc(Cl)cc6Cl
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| InChI |
InChI=1S/C31H35Cl2N3O3/c1-31(16-23-17-35-27-5-3-2-4-25(23)27,29(37)34-9-8-20-6-7-24(32)15-26(20)33)36-30(38)39-28-21-11-18-10-19(13-21)14-22(28)12-18/h2-7,15,17-19,21-22,28,35H,8-14,16H2,1H3,(H,34,37)(H,36,38)/t18-,19+,21-,22+,28?,31?
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| InChIKey |
IZIFZVHACKDILP-UKZPENQXSA-N
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| Target and Pathway | |||||
| Target(s) | Gastrin/cholecystokinin type B receptor | Target Info | [1] | ||
| Cholecystokinin receptor type A | Target Info | [1] | |||
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Gastric acid secretionhsa04020:Calcium signaling pathway | |||||
| Insulin secretion | |||||
| Pancreatic secretion | |||||
| PANTHER Pathway | CCKR signaling map ST | ||||
| PathWhiz Pathway | Gastric Acid Production | ||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (q) signalling events | |||||
| Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-375276:Peptide ligand-binding receptors | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Secretion of Hydrochloric Acid in Parietal Cells | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like | |||||
| References | |||||
| REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 | ||||
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