Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXH0XO
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| Drug Name |
[5-(2-Fluoro-phenyl)-3-(1H-indol-3-ylmethyl)-3H-benzo[e][1,4]diazepin-2-ylamino]-acetic acid
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| Synonyms |
CHEMBL315184
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| Indication | Discovery agent | Investigative | [1] | ||
| Formula |
C26H21FN4O2
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| Canonical SMILES |
OC(=O)CNC1=Nc2ccccc2C(=N[C@@H]1Cc3c[nH]c4ccccc34)c5ccccc5F
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| InChI |
InChI=1S/C26H21FN4O2/c27-20-10-4-1-8-18(20)25-19-9-3-6-12-22(19)31-26(29-15-24(32)33)23(30-25)13-16-14-28-21-11-5-2-7-17(16)21/h1-12,14,23,28H,13,15H2,(H,29,31)(H,32,33)/t23-/m1/s1
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| InChIKey |
VTLYHPYOFGZVPC-HSZRJFAPSA-N
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| Target and Pathway | |||||
| Target(s) | Gastrin/cholecystokinin type B receptor | Target Info | [1] | ||
| Cholecystokinin receptor type A | Target Info | [1] | |||
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Gastric acid secretionhsa04020:Calcium signaling pathway | |||||
| Insulin secretion | |||||
| Pancreatic secretion | |||||
| PANTHER Pathway | CCKR signaling map ST | ||||
| PathWhiz Pathway | Gastric Acid Production | ||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (q) signalling events | |||||
| Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-375276:Peptide ligand-binding receptors | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Secretion of Hydrochloric Acid in Parietal Cells | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like | |||||
| References | |||||
| REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 | ||||
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