Drug General Information |
Drug ID |
DXEU7Z
|
Drug Name |
1-((4-(4-chlorophenoxy)phenylsulfonyl)methyl)-3-hydroxypyridin-2(1H)-one
|
Synonyms |
CHEMBL257070
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Formula |
C18H14ClNO5S
|
Canonical SMILES |
OC1=CC=CN(CS(=O)(=O)c2ccc(Oc3ccc(Cl)cc3)cc2)C1=O
|
InChI |
InChI=1S/C18H14ClNO5S/c19-13-3-5-14(6-4-13)25-15-7-9-16(10-8-15)26(23,24)12-20-11-1-2-17(21)18(20)22/h1-11,21H,12H2
|
InChIKey |
GLZLLWJIHUOGHO-UHFFFAOYSA-N
|
Target and Pathway |
Target(s) |
72 kDa type IV collagenase |
Target Info |
|
[1]
|
MMP-9 |
Target Info |
|
[1]
|
KEGG Pathway
|
Leukocyte transendothelial migration
|
GnRH signaling pathway
|
Estrogen signaling pathway
|
Pathways in cancer
|
Proteoglycans in cancer
|
Bladder cancerhsa04668:TNF signaling pathway
|
Hepatitis B
|
Transcriptional misregulation in cancer
|
MicroRNAs in cancer
|
Bladder cancer
|
NetPath Pathway
|
Leptin Signaling Pathway
|
TCR Signaling Pathway
|
ID Signaling PathwayNetPath_5:ID Signaling Pathway
|
TWEAK Signaling Pathway
|
TNFalpha Signaling Pathway
|
PANTHER Pathway
|
Alzheimer disease-presenilin pathwayP00004:Alzheimer disease-presenilin pathway
|
Plasminogen activating cascade
|
CCKR signaling map ST
|
Pathway Interaction Database
|
LPA receptor mediated events
|
Plasma membrane estrogen receptor signaling
|
Osteopontin-mediated events
|
Validated transcriptional targets of AP1 family members Fra1 and Fra2
|
Angiopoietin receptor Tie2-mediated signaling
|
Direct p53 effectors
|
amb2 Integrin signaling
|
ATF-2 transcription factor network
|
FOXM1 transcription factor network
|
Regulation of nuclear beta catenin signaling and target gene transcription
|
Syndecan-2-mediated signaling eventslysophospholipid_pathway:LPA receptor mediated events
|
Validated targets of C-MYC transcriptional activation
|
CXCR4-mediated signaling events
|
Syndecan-4-mediated signaling events
|
AP-1 transcription factor network
|
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
|
Syndecan-1-mediated signaling events
|
FGF signaling pathway
|
Reactome
|
Collagen degradation
|
Degradation of the extracellular matrix
|
Activation of Matrix Metalloproteinases
|
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
|
EPH-ephrin mediated repulsion of cellsR-HSA-1442490:Collagen degradation
|
Assembly of collagen fibrils and other multimeric structures
|
EPH-ephrin mediated repulsion of cells
|
WikiPathways
|
Activation of Matrix Metalloproteinases
|
AGE/RAGE pathway
|
Matrix MetalloproteinasesWP474:Endochondral Ossification
|
IL1 and megakaryotyces in obesity
|
Mammary gland development pathway - Involution (Stage 4 of 4)
|
Degradation of collagen
|
Spinal Cord Injury
|
TWEAK Signaling Pathway
|
Angiogenesis
|
Osteopontin Signaling
|
Matrix Metalloproteinases
|
References |
REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 |