Drug General Information |
Drug ID |
DX4VN6
|
Drug Name |
2-(1-(3-chlorophenyl)-1H-1,2,3-triazol-4-yl)-N-(pyridin-2-ylmethyl)aniline
|
Synonyms |
CHEMBL523301
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Formula |
C20H16ClN5
|
Canonical SMILES |
Clc1cccc(c1)n2cc(nn2)c3ccccc3NCc4ccccn4
|
InChI |
InChI=1S/C20H16ClN5/c21-15-6-5-8-17(12-15)26-14-20(24-25-26)18-9-1-2-10-19(18)23-13-16-7-3-4-11-22-16/h1-12,14,23H,13H2
|
InChIKey |
HCNFKUQQFWCLQR-UHFFFAOYSA-N
|
Target and Pathway |
Target(s) |
Vascular endothelial growth factor receptor 2 |
Target Info |
|
[1]
|
Vascular endothelial growth factor receptor 1 |
Target Info |
|
[1]
|
KEGG Pathway
|
Ras signaling pathway
|
Rap1 signaling pathway
|
Cytokine-cytokine receptor interaction
|
Endocytosis
|
PI3K-Akt signaling pathway
|
VEGF signaling pathway
|
Focal adhesion
|
Proteoglycans in cancerhsa04014:Ras signaling pathway
|
HIF-1 signaling pathway
|
Transcriptional misregulation in cancer
|
Rheumatoid arthritis
|
NetPath Pathway
|
IL2 Signaling Pathway
|
PANTHER Pathway
|
Angiogenesis
|
VEGF signaling pathway
|
Pathway Interaction Database
|
HIF-2-alpha transcription factor network
|
Beta3 integrin cell surface interactions
|
Signaling events mediated by TCPTP
|
SHP2 signaling
|
S1P1 pathway
|
VEGF and VEGFR signaling network
|
Integrins in angiogenesis
|
Signaling events mediated by VEGFR1 and VEGFR2
|
Notch-mediated HES/HEY networkglypican_1pathway:Glypican 1 network
|
S1P3 pathway
|
VEGFR1 specific signals
|
Reactome
|
Neurophilin interactions with VEGF and VEGFR
|
VEGF binds to VEGFR leading to receptor dimerization
|
Integrin cell surface interactions
|
EPHA-mediated growth cone collapse
|
VEGFA-VEGFR2 Pathway
|
VEGFR2 mediated cell proliferationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
|
WikiPathways
|
Focal Adhesion
|
Nifedipine Activity
|
Cardiac Progenitor Differentiation
|
Signaling by VEGF
|
AngiogenesisWP306:Focal Adhesion
|
Angiogenesis
|
References |
REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 |