Drug Information

Drug General Information
Drug ID
DX4QH9
Drug Name
2-(4-Chloro-phenyl)-N-[5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-acetamide: 0.4H2O
Synonyms
CHEMBL72570
Indication Discovery agent Investigative [1587926]
Formula
C23H17ClFN3O2
Canonical SMILES
Fc1ccccc1C2=NC(NC(=O)Cc3ccc(Cl)cc3)C(=O)Nc4ccccc24
InChI
InChI=1S/C23H17ClFN3O2/c24-15-11-9-14(10-12-15)13-20(29)27-22-23(30)26-19-8-4-2-6-17(19)21(28-22)16-5-1-3-7-18(16)25/h1-12,22H,13H2,(H,26,30)(H,27,29)
InChIKey
QJGLJQLSDWKUHQ-UHFFFAOYSA-N
Target and Pathway
Target(s) Gastrin/cholecystokinin type B receptor Target Info [1587926]
Cholecystokinin receptor type A Target Info [1587926]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretionhsa04020:Calcium signaling pathway
Insulin secretion
Pancreatic secretion
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-375276:Peptide ligand-binding receptors
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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