Drug Information

Drug General Information
Drug ID
DXT2MM
Drug Name
2-[2-(Decahydro-naphthalen-1-ylmethyl)-4-hydroxy-3,6-dioxo-cyclohexa-1,4-dienylamino]-3-hydroxy-butyric acid
Synonyms
CHEMBL442388
Indication Discovery agent Investigative [1587926]
Formula
C21H29NO6
Canonical SMILES
CC(O)C(\\N=C\\1/C(=CC(=O)C(=C1CC2CCCC3CCCCC23)O)O)C(=O)O
InChI
InChI=1S/C21H29NO6/c1-11(23)18(21(27)28)22-19-15(20(26)17(25)10-16(19)24)9-13-7-4-6-12-5-2-3-8-14(12)13/h10-14,18,23-24,26H,2-9H2,1H3,(H,27,28)/b22-19-
InChIKey
UGIUMAONBACZQP-QOCHGBHMSA-N
Target and Pathway
Target(s) Insulin-like growth factor I receptor Target Info [1587926]
Angiopoietin 1 receptor Target Info [1587926]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Oocyte meiosis
Endocytosis
PI3K-Akt signaling pathway
AMPK signaling pathway
Focal adhesion
Adherens junction
Signaling pathways regulating pluripotency of stem cells
Long-term depression
Ovarian steroidogenesis
Progesterone-mediated oocyte maturation
Pathways in cancer
Transcriptional misregulation in cancer
Proteoglycans in cancer
Glioma
Prostate cancer
Melanomahsa04014:Ras signaling pathway
Rheumatoid arthritis
NetPath Pathway Wnt Signaling Pathway
PANTHER Pathway Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Insulin/IGF pathway-protein kinase B signaling cascadeP00005:Angiogenesis
Pathway Interaction Database Plasma membrane estrogen receptor signaling
SHP2 signaling
IGF1 pathway
Posttranslational regulation of adherens junction stability and dissassembly
Integrins in angiogenesis
Stabilization and expansion of the E-cadherin adherens junctionangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling
Reactome IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1RR-HSA-210993:Tie2 Signaling
RAF/MAP kinase cascade
WikiPathways Senescence and Autophagy in Cancer
Insulin Signaling
Endochondral Ossification
Focal Adhesion
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Apoptosis
Signaling Pathways in Glioblastoma
TSH signaling pathway
MicroRNAs in cardiomyocyte hypertrophyWP363:Wnt Signaling Pathway Netpath
Cell surface interactions at the vascular wall
Angiogenesis
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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