Drug Information

Drug General Information
Drug ID
DX4SDJ
Drug Name
2-[3-(4-{[(Phenylamino)carbonyl]amino}phenyl)-4-(1H-pyrrolo-[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]acetamide
Synonyms
CHEMBL1094505
Indication Discovery agent Investigative [1587926]
Formula
C25H21N7O2
Canonical SMILES
NC(=O)Cn1cc(c2ccnc3[nH]ccc23)c(n1)c4ccc(NC(=O)Nc5ccccc5)cc4
InChI
InChI=1S/C25H21N7O2/c26-22(33)15-32-14-21(19-10-12-27-24-20(19)11-13-28-24)23(31-32)16-6-8-18(9-7-16)30-25(34)29-17-4-2-1-3-5-17/h1-14H,15H2,(H2,26,33)(H,27,28)(H2,29,30,34)
InChIKey
UNYZXVQYBXGDJS-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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