Drug Information
| Drug General Information | |||||
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| Drug ID |
DX7YUG
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| Drug Name |
3-(2-chlorophenyl)-1-methyl-1-((5-(6-((4-methylpiperazin-1-yl)methyl)-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)thiophen-2-yl)methyl)urea
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| Synonyms |
CHEMBL209971
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C29H31ClN6OS
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| Canonical SMILES |
CN(Cc1ccc(s1)c2[nH]nc3c2Cc4cc(CN5CCN(C)CC5)ccc34)C(=O)Nc6ccccc6Cl
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| InChI |
InChI=1S/C29H31ClN6OS/c1-34-11-13-36(14-12-34)17-19-7-9-22-20(15-19)16-23-27(22)32-33-28(23)26-10-8-21(38-26)18-35(2)29(37)31-25-6-4-3-5-24(25)30/h3-10,15H,11-14,16-18H2,1-2H3,(H,31,37)(H,32,33)
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| InChIKey |
LPMGFAMWKXULFT-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Vascular endothelial growth factor receptor 1 | Target Info | [1587926] | |||
| KEGG Pathway | Ras signaling pathway | ||||
| Rap1 signaling pathway | |||||
| Cytokine-cytokine receptor interaction | |||||
| Endocytosis | |||||
| PI3K-Akt signaling pathway | |||||
| VEGF signaling pathway | |||||
| Focal adhesion | |||||
| Proteoglycans in cancerhsa04014:Ras signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Transcriptional misregulation in cancer | |||||
| Rheumatoid arthritis | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathway | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY networkglypican_1pathway:Glypican 1 network | |||||
| S1P3 pathway | |||||
| VEGFR1 specific signals | |||||
| References | |||||
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