Drug General Information |
Drug ID |
DXF1XQ
|
Drug Name |
3-{5-[4-(4-Morpholin-4-yl-phenylamino)-[1,3,5]triazin-2-yl]-pyridin-3-ylamino}-propan-1-ol
|
Synonyms |
CHEMBL191377
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Formula |
C21H25N7O2
|
Canonical SMILES |
OCCCNc1cncc(c1)c2ncnc(Nc3ccc(cc3)N4CCOCC4)n2
|
InChI |
InChI=1S/C21H25N7O2/c29-9-1-6-23-18-12-16(13-22-14-18)20-24-15-25-21(27-20)26-17-2-4-19(5-3-17)28-7-10-30-11-8-28/h2-5,12-15,23,29H,1,6-11H2,(H,24,25,26,27)
|
InChIKey |
RITLUZRZBLXNNE-UHFFFAOYSA-N
|
Target and Pathway |
Target(s) |
Cell division control protein 2 homolog |
Target Info |
|
[1]
|
Vascular endothelial growth factor receptor 2 |
Target Info |
|
[1]
|
Vascular endothelial growth factor receptor 2 |
Target Info |
|
[1]
|
Cell division control protein 2 homolog |
Target Info |
|
[1]
|
KEGG Pathway
|
Cell cycle
|
Oocyte meiosis
|
p53 signaling pathway
|
Gap junction
|
Progesterone-mediated oocyte maturation
|
Herpes simplex infection
|
Epstein-Barr virus infection
|
Viral carcinogenesishsa04014:Ras signaling pathway
|
Rap1 signaling pathway
|
Cytokine-cytokine receptor interaction
|
Endocytosis
|
PI3K-Akt signaling pathway
|
VEGF signaling pathway
|
Focal adhesion
|
Proteoglycans in cancer
|
NetPath Pathway
|
RANKL Signaling PathwayNetPath_14:IL2 Signaling Pathway
|
PANTHER Pathway
|
Angiogenesis
|
VEGF signaling pathway
|
Pathway Interaction Database
|
p73 transcription factor network
|
E2F transcription factor network
|
PLK1 signaling events
|
AP-1 transcription factor network
|
FOXM1 transcription factor network
|
Retinoic acid receptors-mediated signalinghif2pathway:HIF-2-alpha transcription factor network
|
Beta3 integrin cell surface interactions
|
Signaling events mediated by TCPTP
|
SHP2 signaling
|
S1P1 pathway
|
VEGF and VEGFR signaling network
|
Integrins in angiogenesis
|
Signaling events mediated by VEGFR1 and VEGFR2
|
Notch-mediated HES/HEY network
|
Reactome
|
MAPK3 (ERK1) activation
|
E2F mediated regulation of DNA replication
|
G0 and Early G1
|
Cyclin B2 mediated events
|
Golgi Cisternae Pericentriolar Stack Reorganization
|
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
|
Regulation of APC/C activators between G1/S and early anaphase
|
Phosphorylation of the APC/C
|
Phosphorylation of Emi1
|
Condensation of Prophase Chromosomes
|
MASTL Facilitates Mitotic Progression
|
Resolution of Sister Chromatid Cohesion
|
Condensation of Prometaphase Chromosomes
|
Regulation of PLK1 Activity at G2/M Transition
|
Activation of NIMA Kinases NEK9, NEK6, NEK7
|
Loss of Nlp from mitotic centrosomes
|
Recruitment of mitotic centrosome proteins and complexes
|
Loss of proteins required for interphase microtubule organization?from the centrosome
|
Recruitment of NuMA to mitotic centrosomes
|
Depolymerisation of the Nuclear Lamina
|
Anchoring of the basal body to the plasma membrane
|
MAPK6/MAPK4 signaling
|
G1/S-Specific Transcription
|
Cyclin A/B1 associated events during G2/M transition
|
G2/M DNA replication checkpoint
|
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
|
VEGF binds to VEGFR leading to receptor dimerization
|
Integrin cell surface interactions
|
EPHA-mediated growth cone collapse
|
VEGFA-VEGFR2 Pathway
|
VEGFR2 mediated cell proliferation
|
WikiPathways
|
DNA Damage Response
|
G1 to S cell cycle control
|
TGF beta Signaling Pathway
|
PPAR Alpha Pathway
|
MAP kinase activation in TLR cascade
|
RAF/MAP kinase cascade
|
Mitotic Prophase
|
Mitotic Prometaphase
|
BMI1
|
ATM Signaling Pathway
|
Retinoblastoma (RB) in Cancer
|
Spinal Cord Injury
|
Prostate Cancer
|
Regulation of Microtubule Cytoskeleton
|
Integrated Cancer pathway
|
Mitotic G2-G2/M phases
|
Mitotic G1-G1/S phases
|
Cell Cycle
|
APC/C-mediated degradation of cell cycle proteins
|
Cell Cycle Checkpoints
|
miRNA Regulation of DNA Damage ResponseWP306:Focal Adhesion
|
Nifedipine Activity
|
Cardiac Progenitor Differentiation
|
Signaling by VEGF
|
Angiogenesis
|
References |
REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 |