| Drug General Information |
| Drug ID |
DXJ6TL
|
| Drug Name |
4-(2-(3-(4-(trifluoromethyl)-1H-imidazol-2-yl)-1H-pyrazol-4-yl)vinyl)isoquinoline
|
| Synonyms |
CHEMBL246167
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Formula |
C18H12F3N5
|
| Canonical SMILES |
FC(F)(F)c1c[nH]c(n1)c2n[nH]cc2\\C=C\\c3cncc4ccccc34
|
| InChI |
InChI=1S/C18H12F3N5/c19-18(20,21)15-10-23-17(25-15)16-13(9-24-26-16)6-5-12-8-22-7-11-3-1-2-4-14(11)12/h1-10H,(H,23,25)(H,24,26)/b6-5+
|
| InChIKey |
FVEOSFBMLSDRHJ-AATRIKPKSA-N
|
| Target and Pathway |
| Target(s) |
Aurora kinase A |
Target Info |
|
[1]
|
|---|
| Vascular endothelial growth factor receptor 2 |
Target Info |
|
[1]
|
| Vascular endothelial growth factor receptor 2 |
Target Info |
|
[1]
|
| Aurora kinase A |
Target Info |
|
[1]
|
|
KEGG Pathway
|
Oocyte meiosishsa04014:Ras signaling pathway
|
|
Rap1 signaling pathway
|
|
Cytokine-cytokine receptor interaction
|
|
Endocytosis
|
|
PI3K-Akt signaling pathway
|
|
VEGF signaling pathway
|
|
Focal adhesion
|
|
Proteoglycans in cancer
|
|
NetPath Pathway
|
IL2 Signaling Pathway
|
|
PANTHER Pathway
|
Angiogenesis
|
|
VEGF signaling pathway
|
|
Pathway Interaction Database
|
Aurora B signaling
|
|
Signaling by Aurora kinases
|
|
Integrin-linked kinase signaling
|
|
PLK1 signaling events
|
|
Aurora A signalinghif2pathway:HIF-2-alpha transcription factor network
|
|
Beta3 integrin cell surface interactions
|
|
Signaling events mediated by TCPTP
|
|
SHP2 signaling
|
|
S1P1 pathway
|
|
VEGF and VEGFR signaling network
|
|
Integrins in angiogenesis
|
|
Signaling events mediated by VEGFR1 and VEGFR2
|
|
Notch-mediated HES/HEY network
|
|
Reactome
|
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
|
|
Regulation of PLK1 Activity at G2/M TransitionR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
|
|
VEGF binds to VEGFR leading to receptor dimerization
|
|
Integrin cell surface interactions
|
|
EPHA-mediated growth cone collapse
|
|
VEGFA-VEGFR2 Pathway
|
|
VEGFR2 mediated cell proliferation
|
|
WikiPathways
|
EGF/EGFR Signaling Pathway
|
|
JAK/STAT
|
|
Gastric Cancer Network 1
|
|
Integrated Breast Cancer Pathway
|
|
APC/C-mediated degradation of cell cycle proteinsWP306:Focal Adhesion
|
|
Nifedipine Activity
|
|
Cardiac Progenitor Differentiation
|
|
Signaling by VEGF
|
|
Angiogenesis
|
| References |
| REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 |
|---|
