Drug General Information |
Drug ID |
DX8IH3
|
Drug Name |
4-(4-(7-(2-fluoro-4-(2-oxo-3-phenylimidazolidine-1-carboxamido)phenoxy)thieno[3,2-b]pyridin-2-yl)benzyl)-N-methylpiperazine-1-carboxamide
|
Synonyms |
CHEMBL503016
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Formula |
C36H34FN7O4S
|
Canonical SMILES |
CNC(=O)N1CCN(Cc2ccc(cc2)c3cc4nccc(Oc5ccc(NC(=O)N6CCN(C6=O)c7ccccc7)cc5F)c4s3)CC1
|
InChI |
InChI=1S/C36H34FN7O4S/c1-38-34(45)42-17-15-41(16-18-42)23-24-7-9-25(10-8-24)32-22-29-33(49-32)31(13-14-39-29)48-30-12-11-26(21-28(30)37)40-35(46)44-20-19-43(36(44)47)27-5-3-2-4-6-27/h2-14,21-22H,15-20,23H2,1H3,(H,38,45)(H,40,46)
|
InChIKey |
WOBLFEIWTSKVMT-UHFFFAOYSA-N
|
Target and Pathway |
Target(s) |
Hepatocyte growth factor receptor |
Target Info |
|
[1]
|
Vascular endothelial growth factor receptor 2 |
Target Info |
|
[1]
|
Vascular endothelial growth factor receptor 2 |
Target Info |
|
[1]
|
Hepatocyte growth factor receptor |
Target Info |
|
[1]
|
KEGG Pathway
|
Ras signaling pathway
|
Rap1 signaling pathway
|
Cytokine-cytokine receptor interaction
|
Endocytosis
|
PI3K-Akt signaling pathway
|
Axon guidance
|
Focal adhesion
|
Adherens junction
|
Bacterial invasion of epithelial cells
|
Epithelial cell signaling in Helicobacter pylori infection
|
Malaria
|
Pathways in cancer
|
Transcriptional misregulation in cancer
|
Proteoglycans in cancer
|
MicroRNAs in cancer
|
Renal cell carcinoma
|
Melanoma
|
Central carbon metabolism in cancerhsa04014:Ras signaling pathway
|
VEGF signaling pathway
|
NetPath Pathway
|
IL2 Signaling Pathway
|
PANTHER Pathway
|
Angiogenesis
|
VEGF signaling pathway
|
Pathway Interaction Database
|
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
|
Arf6 signaling events
|
Signaling events mediated by TCPTP
|
Posttranslational regulation of adherens junction stability and dissassembly
|
Direct p53 effectors
|
Syndecan-1-mediated signaling events
|
Stabilization and expansion of the E-cadherin adherens junction
|
a6b1 and a6b4 Integrin signaling
|
FGF signaling pathway
|
Regulation of retinoblastoma proteinhif2pathway:HIF-2-alpha transcription factor network
|
Beta3 integrin cell surface interactions
|
SHP2 signaling
|
S1P1 pathway
|
VEGF and VEGFR signaling network
|
Integrins in angiogenesis
|
Signaling events mediated by VEGFR1 and VEGFR2
|
Notch-mediated HES/HEY network
|
Reactome
|
Sema4D mediated inhibition of cell attachment and migrationR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
|
VEGF binds to VEGFR leading to receptor dimerization
|
Integrin cell surface interactions
|
EPHA-mediated growth cone collapse
|
VEGFA-VEGFR2 Pathway
|
VEGFR2 mediated cell proliferation
|
WikiPathways
|
TGF beta Signaling Pathway
|
Signaling of Hepatocyte Growth Factor Receptor
|
Focal Adhesion
|
Extracellular vesicle-mediated signaling in recipient cells
|
Signaling Pathways in Glioblastoma
|
miR-targeted genes in squamous cell - TarBase
|
miR-targeted genes in muscle cell - TarBase
|
miR-targeted genes in lymphocytes - TarBase
|
miR-targeted genes in epithelium - TarBase
|
Semaphorin interactionsWP306:Focal Adhesion
|
Nifedipine Activity
|
Cardiac Progenitor Differentiation
|
Signaling by VEGF
|
Angiogenesis
|
References |
REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 |