Drug Information

Drug General Information
Drug ID
DX5XOT
Drug Name
4-[3-(4-N-Phenylcarbamylaminophenyl)-1-ethyl-1H-pyrazol-4-yl]-2-[3-(dimethylaminomethyl)-6-methyl-phenyl]-1H-pyrrolo-[2,3-b]pyridine
Synonyms
CHEMBL1099346
Indication Discovery agent Investigative [1587926]
Formula
C35H35N7O
Canonical SMILES
CCn1cc(c2ccnc3[nH]c(cc23)c4cc(CN(C)C)ccc4C)c(n1)c5ccc(NC(=O)Nc6ccccc6)cc5
InChI
InChI=1S/C35H35N7O/c1-5-42-22-31(33(40-42)25-13-15-27(16-14-25)38-35(43)37-26-9-7-6-8-10-26)28-17-18-36-34-30(28)20-32(39-34)29-19-24(21-41(3)4)12-11-23(29)2/h6-20,22H,5,21H2,1-4H3,(H,36,39)(H2,37,38,43)
InChIKey
KJAGZTFLBMDQQT-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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