| Drug General Information |
| Drug ID |
DX4CML
|
| Drug Name |
4-amino-5-(4-(benzenesulfonylamino)-phenyl)-6-(3-pyridyl)-furo[2,3-d]pyrimidine
|
| Synonyms |
CHEMBL258081
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Formula |
C23H17N5O3S
|
| Canonical SMILES |
Nc1ncnc2oc(c3cccnc3)c(c4ccc(NS(=O)(=O)c5ccccc5)cc4)c12
|
| InChI |
InChI=1S/C23H17N5O3S/c24-22-20-19(21(16-5-4-12-25-13-16)31-23(20)27-14-26-22)15-8-10-17(11-9-15)28-32(29,30)18-6-2-1-3-7-18/h1-14,28H,(H2,24,26,27)
|
| InChIKey |
XFTFQOAUKKRYKT-UHFFFAOYSA-N
|
| Target and Pathway |
| Target(s) |
Glycogen synthase kinase-3 |
Target Info |
|
[1]
|
|---|
| Vascular endothelial growth factor receptor 2 |
Target Info |
|
[1]
|
|
KEGG Pathway
|
Ras signaling pathway
|
|
Rap1 signaling pathway
|
|
Cytokine-cytokine receptor interaction
|
|
Endocytosis
|
|
PI3K-Akt signaling pathway
|
|
VEGF signaling pathway
|
|
Focal adhesion
|
|
Proteoglycans in cancer
|
|
NetPath Pathway
|
TGF_beta_Receptor Signaling PathwayNetPath_14:IL2 Signaling Pathway
|
|
PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Insulin/IGF pathway-protein kinase B signaling cascade
|
|
PDGF signaling pathway
|
|
Ras PathwayP00005:Angiogenesis
|
|
VEGF signaling pathway
|
|
Pathway Interaction Database
|
Degradation of beta catenin
|
|
Canonical Wnt signaling pathway
|
|
FOXM1 transcription factor network
|
|
Class I PI3K signaling events mediated by Akthif2pathway:HIF-2-alpha transcription factor network
|
|
Beta3 integrin cell surface interactions
|
|
Signaling events mediated by TCPTP
|
|
SHP2 signaling
|
|
S1P1 pathway
|
|
VEGF and VEGFR signaling network
|
|
Integrins in angiogenesis
|
|
Signaling events mediated by VEGFR1 and VEGFR2
|
|
Notch-mediated HES/HEY network
|
|
Reactome
|
AKT phosphorylates targets in the cytosol
|
|
XBP1(S) activates chaperone genes
|
|
Constitutive Signaling by AKT1 E17K in CancerR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
|
|
VEGF binds to VEGFR leading to receptor dimerization
|
|
Integrin cell surface interactions
|
|
EPHA-mediated growth cone collapse
|
|
VEGFA-VEGFR2 Pathway
|
|
VEGFR2 mediated cell proliferation
|
|
WikiPathways
|
Focal Adhesion
|
|
Nifedipine Activity
|
|
Cardiac Progenitor Differentiation
|
|
Signaling by VEGF
|
|
Angiogenesis
|
| References |
| REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 |
|---|
