Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX0TKT
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| Drug Name |
5-Amino-3-(2-ethoxy-ethyl)-3-{4-[4-(2H-pyrazol-3-yl)-phenoxy]-phenoxy}-piperidine-2,4,6-trione
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| Synonyms |
CHEMBL359519
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| Indication | Discovery agent | Investigative | [1] | ||
| Formula |
C24H24N4O6
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| Canonical SMILES |
CCOCCC1(Oc2ccc(Oc3ccc(cc3)c4cc[nH]n4)cc2)C(=O)NC(=O)C(N)C1=O
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| InChI |
InChI=1S/C24H24N4O6/c1-2-32-14-12-24(21(29)20(25)22(30)27-23(24)31)34-18-9-7-17(8-10-18)33-16-5-3-15(4-6-16)19-11-13-26-28-19/h3-11,13,20H,2,12,14,25H2,1H3,(H,26,28)(H,27,30,31)
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| InChIKey |
SLUQTAQKAIYNRS-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Collagenase 3 | Target Info | [1] | ||
| Matrix metalloproteinase-14 | Target Info | [1] | |||
| KEGG Pathway | TNF signaling pathway | ||||
| GnRH signaling pathway | |||||
| NetPath Pathway | IL1 Signaling Pathway | ||||
| PANTHER Pathway | Alzheimer disease-presenilin pathway | ||||
| Plasminogen activating cascadeP00004:Alzheimer disease-presenilin pathway | |||||
| Pathway Interaction Database | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalinghif2pathway:HIF-2-alpha transcription factor network | ||||
| Signaling events mediated by focal adhesion kinase | |||||
| Reactome | Collagen degradation | ||||
| Degradation of the extracellular matrix | |||||
| Activation of Matrix Metalloproteinases | |||||
| Assembly of collagen fibrils and other multimeric structuresR-HSA-1442490:Collagen degradation | |||||
| WikiPathways | Endochondral Ossification | ||||
| Activation of Matrix Metalloproteinases | |||||
| Oncostatin M Signaling Pathway | |||||
| AGE/RAGE pathway | |||||
| Matrix MetalloproteinasesWP615:Senescence and Autophagy in Cancer | |||||
| Degradation of collagen | |||||
| Matrix Metalloproteinases | |||||
| References | |||||
| REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 | ||||
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