| Drug General Information |
| Drug ID |
DXO2KQ
|
| Drug Name |
6-methoxy-2-(4-(2-(4-methylpyridin-3-yl)vinyl)-1H-pyrazol-3-yl)-1H-benzo[d]imidazole
|
| Synonyms |
CHEMBL245574
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Formula |
C19H17N5O
|
| Canonical SMILES |
COc1ccc2nc([nH]c2c1)c3n[nH]cc3\\C=C\\c4cnccc4C
|
| InChI |
InChI=1S/C19H17N5O/c1-12-7-8-20-10-13(12)3-4-14-11-21-24-18(14)19-22-16-6-5-15(25-2)9-17(16)23-19/h3-11H,1-2H3,(H,21,24)(H,22,23)/b4-3+
|
| InChIKey |
WZMDQWFGHYPLKD-ONEGZZNKSA-N
|
| Target and Pathway |
| Target(s) |
Aurora kinase A |
Target Info |
|
[1]
|
|---|
| Vascular endothelial growth factor receptor 2 |
Target Info |
|
[1]
|
| Vascular endothelial growth factor receptor 2 |
Target Info |
|
[1]
|
| Aurora kinase A |
Target Info |
|
[1]
|
|
KEGG Pathway
|
Oocyte meiosishsa04014:Ras signaling pathway
|
|
Rap1 signaling pathway
|
|
Cytokine-cytokine receptor interaction
|
|
Endocytosis
|
|
PI3K-Akt signaling pathway
|
|
VEGF signaling pathway
|
|
Focal adhesion
|
|
Proteoglycans in cancer
|
|
NetPath Pathway
|
IL2 Signaling Pathway
|
|
PANTHER Pathway
|
Angiogenesis
|
|
VEGF signaling pathway
|
|
Pathway Interaction Database
|
Aurora B signaling
|
|
Signaling by Aurora kinases
|
|
Integrin-linked kinase signaling
|
|
PLK1 signaling events
|
|
Aurora A signalinghif2pathway:HIF-2-alpha transcription factor network
|
|
Beta3 integrin cell surface interactions
|
|
Signaling events mediated by TCPTP
|
|
SHP2 signaling
|
|
S1P1 pathway
|
|
VEGF and VEGFR signaling network
|
|
Integrins in angiogenesis
|
|
Signaling events mediated by VEGFR1 and VEGFR2
|
|
Notch-mediated HES/HEY network
|
|
Reactome
|
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
|
|
Regulation of PLK1 Activity at G2/M TransitionR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
|
|
VEGF binds to VEGFR leading to receptor dimerization
|
|
Integrin cell surface interactions
|
|
EPHA-mediated growth cone collapse
|
|
VEGFA-VEGFR2 Pathway
|
|
VEGFR2 mediated cell proliferation
|
|
WikiPathways
|
EGF/EGFR Signaling Pathway
|
|
JAK/STAT
|
|
Gastric Cancer Network 1
|
|
Integrated Breast Cancer Pathway
|
|
APC/C-mediated degradation of cell cycle proteinsWP306:Focal Adhesion
|
|
Nifedipine Activity
|
|
Cardiac Progenitor Differentiation
|
|
Signaling by VEGF
|
|
Angiogenesis
|
| References |
| REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 |
|---|
