Drug General Information |
Drug ID |
DXZ22S
|
Drug Name |
7-Benzyl-6-phenyl-5H-pyrrolo[2,3-b]pyrazine
|
Synonyms |
CHEMBL77469
|
Indication |
Discovery agent
|
Investigative |
[1]
|
Formula |
C19H15N3
|
Canonical SMILES |
C(c1ccccc1)c2c([nH]c3nccnc23)c4ccccc4
|
InChI |
InChI=1S/C19H15N3/c1-3-7-14(8-4-1)13-16-17(15-9-5-2-6-10-15)22-19-18(16)20-11-12-21-19/h1-12H,13H2,(H,21,22)
|
InChIKey |
CBALVKLWBKZXIX-UHFFFAOYSA-N
|
Target and Pathway |
Target(s) |
Cell division control protein 2 homolog |
Target Info |
|
[1]
|
Glycogen synthase kinase-3 |
Target Info |
|
[1]
|
KEGG Pathway
|
Cell cycle
|
Oocyte meiosis
|
p53 signaling pathway
|
Gap junction
|
Progesterone-mediated oocyte maturation
|
Herpes simplex infection
|
Epstein-Barr virus infection
|
Viral carcinogenesis
|
NetPath Pathway
|
RANKL Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
|
PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
Insulin/IGF pathway-protein kinase B signaling cascade
|
PDGF signaling pathway
|
Ras Pathway
|
Pathway Interaction Database
|
p73 transcription factor network
|
E2F transcription factor network
|
PLK1 signaling events
|
AP-1 transcription factor network
|
FOXM1 transcription factor network
|
Retinoic acid receptors-mediated signalingbetacatenin_deg_pathway:Degradation of beta catenin
|
Canonical Wnt signaling pathway
|
Class I PI3K signaling events mediated by Akt
|
Reactome
|
MAPK3 (ERK1) activation
|
E2F mediated regulation of DNA replication
|
G0 and Early G1
|
Cyclin B2 mediated events
|
Golgi Cisternae Pericentriolar Stack Reorganization
|
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
|
Regulation of APC/C activators between G1/S and early anaphase
|
Phosphorylation of the APC/C
|
Phosphorylation of Emi1
|
Condensation of Prophase Chromosomes
|
MASTL Facilitates Mitotic Progression
|
Resolution of Sister Chromatid Cohesion
|
Condensation of Prometaphase Chromosomes
|
Regulation of PLK1 Activity at G2/M Transition
|
Activation of NIMA Kinases NEK9, NEK6, NEK7
|
Loss of Nlp from mitotic centrosomes
|
Recruitment of mitotic centrosome proteins and complexes
|
Loss of proteins required for interphase microtubule organization?from the centrosome
|
Recruitment of NuMA to mitotic centrosomes
|
Depolymerisation of the Nuclear Lamina
|
Anchoring of the basal body to the plasma membrane
|
MAPK6/MAPK4 signaling
|
G1/S-Specific Transcription
|
Cyclin A/B1 associated events during G2/M transition
|
G2/M DNA replication checkpoint
|
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-198323:AKT phosphorylates targets in the cytosol
|
XBP1(S) activates chaperone genes
|
Constitutive Signaling by AKT1 E17K in Cancer
|
WikiPathways
|
DNA Damage Response
|
G1 to S cell cycle control
|
TGF beta Signaling Pathway
|
PPAR Alpha Pathway
|
MAP kinase activation in TLR cascade
|
RAF/MAP kinase cascade
|
Mitotic Prophase
|
Mitotic Prometaphase
|
BMI1
|
ATM Signaling Pathway
|
Retinoblastoma (RB) in Cancer
|
Spinal Cord Injury
|
Prostate Cancer
|
Regulation of Microtubule Cytoskeleton
|
Integrated Cancer pathway
|
Mitotic G2-G2/M phases
|
Mitotic G1-G1/S phases
|
Cell Cycle
|
APC/C-mediated degradation of cell cycle proteins
|
Cell Cycle Checkpoints
|
miRNA Regulation of DNA Damage Response
|
References |
REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 |