Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXL7TM
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| Drug Name |
N-(1-Methyl-cyclohexyl)-2-[(3R,5S,7R)-2-oxo-7-phenyl-5-o-tolyl-3-(3-m-tolyl-ureido)-azepan-1-yl]-acetamide
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| Synonyms |
CHEMBL329735
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| Indication | Discovery agent | Investigative | [1] | ||
| Formula |
C36H44N4O3
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| Canonical SMILES |
Cc1cccc(NC(=O)N[C@@H]2C[C@@H](C[C@@H](N(CC(=O)NC3(C)CCCCC3)C2=O)c4ccccc4)c5ccccc5C)c1
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| InChI |
InChI=1S/C36H44N4O3/c1-25-13-12-17-29(21-25)37-35(43)38-31-22-28(30-18-9-8-14-26(30)2)23-32(27-15-6-4-7-16-27)40(34(31)42)24-33(41)39-36(3)19-10-5-11-20-36/h4,6-9,12-18,21,28,31-32H,5,10-11,19-20,22-24H2,1-3H3,(H,39,41)(H2,37,38,43)/t28-,31+,32+/m0/s1
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| InChIKey |
GWSFJWULDCAOKV-AVXDPSIRSA-N
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| Target and Pathway | |||||
| Target(s) | Gastrin/cholecystokinin type B receptor | Target Info | [1] | ||
| Cholecystokinin receptor type A | Target Info | [1] | |||
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Gastric acid secretionhsa04020:Calcium signaling pathway | |||||
| Insulin secretion | |||||
| Pancreatic secretion | |||||
| PANTHER Pathway | CCKR signaling map ST | ||||
| PathWhiz Pathway | Gastric Acid Production | ||||
| Reactome | Peptide ligand-binding receptors | ||||
| G alpha (q) signalling events | |||||
| Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-375276:Peptide ligand-binding receptors | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| Secretion of Hydrochloric Acid in Parietal Cells | |||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like | |||||
| References | |||||
| REF 1 | URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017 | ||||
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