Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXM02A
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| Drug Name |
N-[1-(2S-Ethyl-4-oxo-tetrahydro-furan-3S-ylcarbamoyl)-2S-(1-methyl-cyclopentyl)-ethyl]-4-(4-isopropyl-thiazole-2-sulfonylamino)-benzamide
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| Synonyms |
CHEMBL474257
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C28H38N4O6S2
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| Canonical SMILES |
CC[C@@H]1OCC(=O)[C@H]1NC(=O)[C@H](CC2(C)CCCC2)NC(=O)c3ccc(NS(=O)(=O)c4nc(cs4)C(C)C)cc3
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| InChI |
InChI=1S/C28H38N4O6S2/c1-5-23-24(22(33)15-38-23)31-26(35)20(14-28(4)12-6-7-13-28)29-25(34)18-8-10-19(11-9-18)32-40(36,37)27-30-21(16-39-27)17(2)3/h8-11,16-17,20,23-24,32H,5-7,12-15H2,1-4H3,(H,29,34)(H,31,35)/t20-,23-,24+/m0/s1
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| InChIKey |
QUIQWGISSRRKQP-NKKJXINNSA-N
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| Target and Pathway | |||||
| Target(s) | Cathepsin K | Target Info | [1587926] | ||
| Cathepsin L | Target Info | [1587926] | |||
| Reactome | Collagen degradation | ||||
| Degradation of the extracellular matrix | |||||
| Activation of Matrix Metalloproteinases | |||||
| Trafficking and processing of endosomal TLR | |||||
| MHC class II antigen presentationR-HSA-1236977:Endosomal/Vacuolar pathway | |||||
| Assembly of collagen fibrils and other multimeric structures | |||||
| MHC class II antigen presentation | |||||
| References | |||||
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