Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXC8JS
|
||||
| Drug Name |
N-[4-(4-Benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl]-2-morpholin-4-ylmethyl-acrylamide
|
||||
| Synonyms |
CHEMBL179607
|
||||
| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C33H32ClN5O4
|
||||
| Canonical SMILES |
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccc4)c(Cl)c3)c2cc1NC(=O)C(=C)CN5CCOCC5
|
||||
| InChI |
InChI=1S/C33H32ClN5O4/c1-3-42-31-17-28-26(16-29(31)38-33(40)22(2)20-39-11-13-41-14-12-39)32(24(18-35)19-36-28)37-25-9-10-30(27(34)15-25)43-21-23-7-5-4-6-8-23/h4-10,15-17,19H,2-3,11-14,20-21H2,1H3,(H,36,37)(H,38,40)
|
||||
| InChIKey |
GASRAFPOGFLNOD-UHFFFAOYSA-N
|
||||
| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.