Drug Information
Drug General Information | |||||
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Drug ID |
D0HW3Y
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Former ID |
DNC005895
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Drug Name |
5,6-dihydroxy-7-nitro-2,3-dihydroinden-1-one
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [1] | ||
Structure |
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Download2D MOL |
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Formula |
C9H7NO5
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Canonical SMILES |
C1CC(=O)C2=C(C(=C(C=C21)O)O)[N+](=O)[O-]
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InChI |
1S/C9H7NO5/c11-5-2-1-4-3-6(12)9(13)8(7(4)5)10(14)15/h3,12-13H,1-2H2
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InChIKey |
ULOQNEJBWLIGHK-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Catechol-O-methyl-transferase | Target Info | Inhibitor | [1] | |
BioCyc Pathway | L-dopa degradation | ||||
Dopamine degradation | |||||
Noradrenaline and adrenaline degradation | |||||
KEGG Pathway | Steroid hormone biosynthesis | ||||
Tyrosine metabolism | |||||
Metabolic pathways | |||||
Dopaminergic synapse | |||||
PANTHER Pathway | Adrenaline and noradrenaline biosynthesis | ||||
Dopamine receptor mediated signaling pathway | |||||
PathWhiz Pathway | Tyrosine Metabolism | ||||
WikiPathways | Methylation Pathways | ||||
Metapathway biotransformation | |||||
Estrogen metabolism | |||||
Biogenic Amine Synthesis | |||||
Dopamine metabolism | |||||
Phase II conjugation | |||||
Neurotransmitter Clearance In The Synaptic Cleft | |||||
References | |||||
REF 1 | J Med Chem. 2005 Dec 15;48(25):8070-8.Synthesis and biological evaluation of a novel series of "ortho-nitrated" inhibitors of catechol-O-methyltransferase. | ||||
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