Drug Information

Drug General Information
Drug ID
D0KL1P
Former ID
DNC011893
Drug Name
PB-28
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541787]
Structure
Download
2D MOL

3D MOL
Formula
C24H38N2O
InChI
InChI=1S/C24H38N2O/c1-27-24-14-6-12-22-20(8-5-13-23(22)24)9-7-15-25-16-18-26(19-17-25)21-10-3-2-4-11-21/h6,12,14,20-21H,2-5,7-11,13,15-19H2,1H3
InChIKey
PHRCDWVPTULQMT-UHFFFAOYSA-N
PubChem Compound ID
10474335
PubChem Substance ID
15497955, 22803755, 29217633, 40601936, 50111715, 57374813, 79192316, 103237360, 103979247, 128917458, 134349098, 137010183, 137322693, 162223136, 174007304, 178103293, 210024069, 210024104, 226785014
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Inhibitor [534094]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 541787(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6681).
Ref 534094J Med Chem. 1996 Jan 5;39(1):176-82.New sigma and 5-HT1A receptor ligands: omega-(tetralin-1-yl)-n-alkylamine derivatives.

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