Drug Information
Drug General Information | |||||
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Drug ID |
D0Y1MW
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Former ID |
DNC000558
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Drug Name |
Difluoromethylornithine
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Drug Type |
Small molecular drug
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Indication | Trypanosoma brucei gambiense infection [ICD9: 86.5; ICD10:B56] | Phase 2 | [523970] | ||
Structure |
Download2D MOL |
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Formula |
C6H13F2N2O2+
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Canonical SMILES |
C(CC(C(F)F)(C(=O)[O-])[NH3+])C[NH3+]
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InChI |
1S/C6H12F2N2O2/c7-4(8)6(10,5(11)12)2-1-3-9/h4H,1-3,9-10H2,(H,11,12)/p+1
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InChIKey |
VLCYCQAOQCDTCN-UHFFFAOYSA-O
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CAS Number |
CAS 67037-37-0
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
ChEBI ID |
ChEBI:41948
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SuperDrug ATC ID |
P01CX03
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SuperDrug CAS ID |
cas=070052129
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Target and Pathway | |||||
Target(s) | Ornithine decarboxylase | Target Info | Inhibitor | [537878] | |
Arginase II, mitochondrial | Target Info | Inhibitor | [535841] | ||
BioCyc Pathway | Putrescine biosynthesis I | ||||
PANTHER Pathway | Ornithine degradation | ||||
CCKR signaling map ST | |||||
Pathway Interaction Database | Validated targets of C-MYC transcriptional activation | ||||
PathWhiz Pathway | Spermidine and Spermine Biosynthesis | ||||
References | |||||
Ref 535841 | Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels. Circulation. 2003 Oct 21;108(16):2000-6. Epub 2003 Sep 29. | ||||
Ref 537878 | An inhibitor of polyamine biosynthesis impairs human polymorphonuclear leukocyte priming by tumor necrosis factor alpha. J Leukoc Biol. 1995 Feb;57(2):282-6. |
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