| Drug General Information |
| Drug ID |
D00YWZ
|
| Former ID |
DNC007461
|
| Drug Name |
3-(4-aminophenyl)thieno[3,2-c]pyridin-4-amine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C13H11N3S
|
| Canonical SMILES |
C1=CC(=CC=C1C2=CSC3=C2C(=NC=C3)N)N
|
| InChI |
1S/C13H11N3S/c14-9-3-1-8(2-4-9)10-7-17-11-5-6-16-13(15)12(10)11/h1-7H,14H2,(H2,15,16)
|
| InChIKey |
RSUCBZJSTXEGSF-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Vascular endothelial growth factor receptor 2 |
Target Info |
Inhibitor |
[1]
|
|---|
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KEGG Pathway
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Ras signaling pathway
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Rap1 signaling pathway
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Cytokine-cytokine receptor interaction
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Endocytosis
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PI3K-Akt signaling pathway
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VEGF signaling pathway
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Focal adhesion
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Proteoglycans in cancer
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NetPath Pathway
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IL2 Signaling Pathway
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PANTHER Pathway
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Angiogenesis
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VEGF signaling pathway
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Pathway Interaction Database
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HIF-2-alpha transcription factor network
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Beta3 integrin cell surface interactions
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Signaling events mediated by TCPTP
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SHP2 signaling
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S1P1 pathway
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VEGF and VEGFR signaling network
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Integrins in angiogenesis
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Signaling events mediated by VEGFR1 and VEGFR2
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Notch-mediated HES/HEY network
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Reactome
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Neurophilin interactions with VEGF and VEGFR
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VEGF binds to VEGFR leading to receptor dimerization
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Integrin cell surface interactions
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EPHA-mediated growth cone collapse
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VEGFA-VEGFR2 Pathway
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VEGFR2 mediated cell proliferation
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WikiPathways
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Focal Adhesion
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Nifedipine Activity
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Cardiac Progenitor Differentiation
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Signaling by VEGF
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Angiogenesis
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| References |
| REF 1 | Bioorg Med Chem Lett. 2007 Mar 1;17(5):1246-9. Epub 2006 Dec 9.Thienopyridine urea inhibitors of KDR kinase. |
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