Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08JWJ
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| Former ID |
DCL000593
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| Drug Name |
PF-1228305
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| Synonyms |
Thelin; Sitaxentan sodium; Sitaxsentan sodium
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| Drug Type |
Small molecular drug
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| Indication | Pulmonary hypertension [ICD9: 416; ICD10:I27.0, I27.2] | Phase 3 | [549974] | ||
| Company |
Pfizer
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| Structure |
|
Download2D MOL |
|||
| Formula |
C18H14ClN2NaO6S2
|
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| Canonical SMILES |
CC1=CC2=C(C=C1CC(=O)C3=C(C=CS3)S(=O)(=O)[N-]C4=C(C(=NO4<br />)C)Cl)OCO2.[Na+]
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| InChI |
1S/C18H14ClN2O6S2.Na/c1-9-5-13-14(26-8-25-13)7-11(9)6-12(22)17-15(3-4-28-17)29(23,24)21-18-16(19)10(2)20-27-18;/h3-5,7H,6,8H2,1-2H3;/q-1;+1
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| InChIKey |
MDTNUYUCUYPIHE-UHFFFAOYSA-N
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| CAS Number |
CAS 210421-64-0
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| PubChem Compound ID | |||||
| PubChem Substance ID |
12015041, 15318680, 16577869, 23613118, 43529705, 50386535, 50386536, 57376728, 135110232, 152159714, 152258321, 160647160, 160692699, 163124765, 164117708, 164233699, 174528310, 179322759, 185971399, 196108027, 198980810, 204360314, 215771094, 225848332, 241051997, 249828035, 252057354, 252110245, 252451460
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| SuperDrug ATC ID |
C02KX03
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| Target and Pathway | |||||
| Target(s) | Endothelin-1 receptor | Target Info | Antagonist | [549974] | |
| NetPath Pathway | IL4 Signaling Pathway | ||||
| PANTHER Pathway | Endothelin signaling pathway | ||||
| Pathway Interaction Database | Endothelins | ||||
| EGFR-dependent Endothelin signaling events | |||||
| References | |||||
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