| Drug General Information |
| Drug ID |
D0I3EY
|
| Former ID |
DNC003228
|
| Drug Name |
5-phenyl-1H-indazol-3-amine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C13H11N3
|
| Canonical SMILES |
C1=CC=C(C=C1)C2=CC3=C(C=C2)NN=C3N
|
| InChI |
1S/C13H11N3/c14-13-11-8-10(6-7-12(11)15-16-13)9-4-2-1-3-5-9/h1-8H,(H3,14,15,16)
|
| InChIKey |
ZCUSNQPYUNLATP-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
16594036, 23625324, 42571050, 56261066, 76949768, 87557769, 99443632, 103608350, 104106953, 139915744, 160968246, 180410798, 229383615, 244266643, 246910019
|
| Target and Pathway |
| Target(s) |
Tyrosine-protein kinase JAK2 |
Target Info |
Inhibitor |
[1]
|
|---|
|
KEGG Pathway
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Chemokine signaling pathway
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PI3K-Akt signaling pathway
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Signaling pathways regulating pluripotency of stem cells
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Jak-STAT signaling pathway
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Cholinergic synapse
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Prolactin signaling pathway
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Adipocytokine signaling pathway
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Leishmaniasis
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Toxoplasmosis
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Tuberculosis
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Measles
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Influenza A
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Herpes simplex infection
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PANTHER Pathway
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Inflammation mediated by chemokine and cytokine signaling pathway
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Interferon-gamma signaling pathway
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JAK/STAT signaling pathway
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PDGF signaling pathway
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PI3 kinase pathway
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CCKR signaling map ST
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Pathway Interaction Database
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Endothelins
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ErbB4 signaling events
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GMCSF-mediated signaling events
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IL4-mediated signaling events
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IL27-mediated signaling events
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Signaling events mediated by PTP1B
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IL12-mediated signaling events
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S1P3 pathway
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SHP2 signaling
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CXCR4-mediated signaling events
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IL5-mediated signaling events
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IFN-gamma pathway
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ErbB2/ErbB3 signaling events
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IL3-mediated signaling events
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IL6-mediated signaling events
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PDGFR-beta signaling pathway
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IL23-mediated signaling events
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Signaling events mediated by Stem cell factor receptor (c-Kit)
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EPO signaling pathway
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Notch-mediated HES/HEY network
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Reactome
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Interleukin-6 signaling
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MAPK3 (ERK1) activation
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MAPK1 (ERK2) activation
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GPVI-mediated activation cascade
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Prolactin receptor signaling
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RMTs methylate histone arginines
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G beta:gamma signalling through PI3Kgamma
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Interleukin-3, 5 and GM-CSF signaling
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RAF activation
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RAF/MAP kinase cascade
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Interferon gamma signaling
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Regulation of IFNG signaling
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Interleukin receptor SHC signaling
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Growth hormone receptor signaling
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Factors involved in megakaryocyte development and platelet production
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WikiPathways
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Serotonin Receptor 2 and STAT3 Signaling
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Type II interferon signaling (IFNG)
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Notch Signaling Pathway
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EPO Receptor Signaling
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EGF/EGFR Signaling Pathway
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IL-4 Signaling Pathway
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IL-6 signaling pathway
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Kit receptor signaling pathway
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IL-3 Signaling Pathway
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Mesodermal Commitment Pathway
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Interleukin-2 signaling
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Signaling by SCF-KIT
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Prolactin receptor signaling
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Growth hormone receptor signaling
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JAK/STAT
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BDNF signaling pathway
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Oncostatin M Signaling Pathway
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Interleukin-11 Signaling Pathway
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AGE/RAGE pathway
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TSLP Signaling Pathway
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IL17 signaling pathway
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Leptin signaling pathway
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TSH signaling pathway
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Interleukin-3, 5 and GM-CSF signaling
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Interferon gamma signaling
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Factors involved in megakaryocyte development and platelet production
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IL-5 Signaling Pathway
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| References |
| REF 1 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. |
|---|
