Drug Information

Drug General Information
Drug ID
D0U8UK
Former ID
DIB019196
Drug Name
compound 101
Synonyms
cmpd101; Takeda compound 101
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531490], [533255]
Structure
Download
2D MOL
Formula
C24H21F3N6O
InChI
InChI=1S/C24H21F3N6O/c1-33-21(31-32-22(33)16-9-11-28-12-10-16)15-29-19-7-4-6-17(13-19)23(34)30-14-18-5-2-3-8-20(18)24(25,26)27/h2-13,29H,14-15H2,1H3,(H,30,34)
InChIKey
WFOVEDJTASPCIR-UHFFFAOYSA-N
PubChem Compound ID
11677079
PubChem Substance ID
16781096, 23774359, 42844013, 79519018, 123055149, 170483728, 252166102, 252166647
Target and Pathway
Target(s) Beta-adrenergic receptor kinase 1 Target Info Inhibitor [531490]
beta adrenergic receptor kinase 2 Target Info Inhibitor [531490]
KEGG Pathway Chemokine signaling pathway
Endocytosis
Glutamatergic synapse
Morphine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Parkinson disease
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
Pathway Interaction Database Signaling events mediated by HDAC Class II
Thromboxane A2 receptor signaling
CXCR4-mediated signaling events
Signaling events mediated by the Hedgehog family
IL8- and CXCR1-mediated signaling events
Reactome Calmodulin induced events
G alpha (q) signalling events
Activation of SMO
WikiPathways Hedgehog Signaling Pathway
DAG and IP3 signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Opioid Signalling
GPCR downstream signaling
References
Ref 531490Molecular mechanism of selectivity among G protein-coupled receptor kinase 2 inhibitors. Mol Pharmacol. 2011 Aug;80(2):294-303.
Ref 533255Role of G Protein-Coupled Receptor Kinases 2 and 3 in ?-Opioid Receptor Desensitization and Internalization. Mol Pharmacol. 2015 Aug;88(2):347-56.
Ref 531490Molecular mechanism of selectivity among G protein-coupled receptor kinase 2 inhibitors. Mol Pharmacol. 2011 Aug;80(2):294-303.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.