Drug Information

Drug General Information
Drug ID
D06SAW
Former ID
DNC000404
Drug Name
CGP 12177
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540766]
Structure
Download
2D MOL

3D MOL
Formula
C14H21N3O3
InChI
InChI=1S/C14H21N3O3/c1-14(2,3)15-7-9(18)8-20-11-6-4-5-10-12(11)17-13(19)16-10/h4-6,9,15,18H,7-8H2,1-3H3,(H2,16,17,19)
InChIKey
UMQUQWCJKFOUGV-UHFFFAOYSA-N
CAS Number
CAS 586-06-1
PubChem Compound ID
2687
PubChem Substance ID
5658898, 7617043, 7978901, 8151744, 11342047, 11362230, 11364849, 11367411, 11369973, 11374333, 11378141, 11487632, 11492592, 11495721, 14872967, 26752094, 29221844, 47736705, 50065247, 50104748, 53476896, 53787210, 56413035, 57321400, 85209004, 85787596, 90341665, 103136565, 103268291, 104301313, 117601052, 124749661, 124879487, 124879488, 126407427, 129390256, 135066686, 135650065, 136352501, 137106958, 162169310, 162916731, 178102045, 179151219, 179236107, 184580094, 228171803
SuperDrug ATC ID
C01CA29
SuperDrug CAS ID
cas=000586061
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Agonist [537970]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540766(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 532).
Ref 537970Effects of several putative beta 3-adrenoceptor agonists on lipolysis in human omental adipocytes. Int J Obes Relat Metab Disord. 1996 May;20(5):428-34.

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