Drug Information

Drug General Information
Drug ID
D07KMN
Former ID
DNC001470
Drug Name
Trimetoquinol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534963]
Structure
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2D MOL

3D MOL
Formula
C19H24ClNO5
Canonical SMILES
COC1=CC(=CC(=C1OC)OC)CC2C3=CC(=C(C=C3CCN2)O)O.Cl
InChI
1S/C19H23NO5.ClH/c1-23-17-7-11(8-18(24-2)19(17)25-3)6-14-13-10-16(22)15(21)9-12(13)4-5-20-14;/h7-10,14,20-22H,4-6H2,1-3H3;1H
InChIKey
UHSXRTHJCJGEKG-UHFFFAOYSA-N
CAS Number
CAS 516-21-2
PubChem Compound ID
29137
PubChem Substance ID
571531, 8170823, 14878010, 34671531, 49986664, 57310757, 75416568, 103670700, 104304669, 134340649, 227820874
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Agonist [534963]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 534963Synthesis and human beta-adrenoceptor activity of 1-(3,5-diiodo-4- methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-6-ol derivatives in vitro. J Med Chem. 2000 Feb 24;43(4):591-8.
Ref 534963Synthesis and human beta-adrenoceptor activity of 1-(3,5-diiodo-4- methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-6-ol derivatives in vitro. J Med Chem. 2000 Feb 24;43(4):591-8.

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