Drug General Information
Drug ID	D0T7AR
Former ID	DIB018518
Drug Name	2-(3-chlorophenyl)histamine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538706]
Structure		Download 2D MOL
Formula	C11H12ClN3
InChI	InChI=1S/C11H12ClN3/c12-9-3-1-2-8(6-9)11-14-7-10(15-11)4-5-13/h1-3,6-7H,4-5,13H2,(H,14,15)
InChIKey	DHGUFKPZDMQBED-UHFFFAOYSA-N
PubChem Compound ID	14827778
PubChem Substance ID	47510100, 48105228, 56469829, 103193253, 127734685, 135649685, 136352272, 216142900, 218502627, 229081902
Target and Pathway
Target(s)	Histamine H1 receptor	Target Info	Agonist	[526569]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	Histamine H1 receptor mediated signaling pathway
Reactome	Histamine receptors
	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	IL-4 Signaling Pathway
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 538706	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1195).
Ref 526569	Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor. J Pharmacol Exp Ther. 2003 Jun;305(3):1104-15. Epub 2003 Mar 6.

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