Drug Information

Drug General Information
Drug ID
D04JXX
Former ID
DIB019689
Drug Name
d[Pen1,Tyr(Me)2]AVP
Synonyms
1-deaminopenicillamine-2-(O-methyl-tyr)-argipressin; dPTyr(Me)AVP
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539409]
Structure
Download
2D MOL
Formula
C49H70N14O12S2
InChI
InChI=1S/C49H70N14O12S2/c1-49(2)24-40(67)57-32(22-28-13-15-29(75-3)16-14-28)43(70)60-33(21-27-9-5-4-6-10-27)44(71)58-31(17-18-37(50)64)42(69)61-34(23-38(51)65)45(72)62-35(26-76-77-49)47(74)63-20-8-12-36(63)46(73)59-30(11-7-19-55-48(53)54)41(68)56-25-39(52)66/h4-6,9-10,13-16,30-36H,7-8,11-12,17-26H2,1-3H3,(H2,50,64)(H2,51,65)(H2,52,66)(H,56,68)(H,57,67)(H,58,71)(H,59,73)(H,60,70)(H,61,69)(H,62,72)(H4,53,54,55)
InChIKey
HNOGCDKPALYUIG-UHFFFAOYSA-N
PubChem Compound ID
119517
PubChem Substance ID
7411508, 24900721, 29300377, 50068608, 51846530, 57339535, 85090376, 103096505, 104408515, 117569667, 135075466, 135652123, 162103284
Target and Pathway
Target(s) Vasopressin V2 receptor Target Info Antagonist [525878]
Vasopressin V1b receptor Target Info Antagonist [534813]
Vasopressin V1a receptor Target Info Antagonist [534813]
KEGG Pathway Neuroactive ligand-receptor interaction
Vasopressin-regulated water reabsorptionhsa04020:Calcium signaling pathway
Vascular smooth muscle contractionhsa04020:Calcium signaling pathway
Vascular smooth muscle contraction
Pathway Interaction Database Arf6 trafficking events
PathWhiz Pathway Vasopressin Regulation of Water Homeostasis
Reactome Vasopressin-like receptors
G alpha (s) signalling events
Vasopressin regulates renal water homeostasis via AquaporinsR-HSA-388479:Vasopressin-like receptors
G alpha (q) signalling eventsR-HSA-388479:Vasopressin-like receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Regulation of Water Balance by Renal Aquaporins
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
References
Ref 539409(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2225).
Ref 525878Binding properties of a selective tritiated vasopressin V2 receptor antagonist, [H]-SR 121463. Kidney Int. 2000 Oct;58(4):1613-22.
Ref 534813Pharmacological characterization of the human vasopressin receptor subtypes stably expressed in Chinese hamster ovary cells. Br J Pharmacol. 1998 Dec;125(7):1463-70.

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