Drug Information

Drug General Information
Drug ID
D08XOT
Former ID
DPR000127
Drug Name
LY467711
Drug Type
Small molecular drug
Indication Neuropathic pain; Migraine [ICD9: 338, 346,780; ICD10:G43, R52, G89] Terminated [547372]
Therapeutic Class
Analgesics
Company
Eli Lilly
Structure
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2D MOL

3D MOL
Formula
C21H29N5O3
Canonical SMILES
CCC(C)OC(=O)C1CC2CC(CCC2CN1)OC3=CC=CC=C3C4=NNN=N4
InChI
1S/C21H29N5O3/c1-3-13(2)28-21(27)18-11-15-10-16(9-8-14(15)12-22-18)29-19-7-5-4-6-17(19)20-23-25-26-24-20/h4-7,13-16,18,22H,3,8-12H2,1-2H3,(H,23,24,25,26)/t13?,14-,15+,16-,18-/m0/s1
InChIKey
GUJDAZQDHPVNBE-VCGNEYLSSA-N
PubChem Compound ID
57340715
PubChem Substance ID
136352805
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Antagonist [536166]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 547372Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015556)
Ref 536166Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.

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