Drug General Information
Drug ID	D0D1KA
Former ID	DNC009539
Drug Name	3-Hydroxy-7-(3-hydroxyphenyl)-1-naphthonitrile
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529595]
Structure		Download 2D MOL 3D MOL
Formula	C17H11NO2
Canonical SMILES	C1=CC(=CC(=C1)O)C2=CC3=C(C=C2)C=C(C=C3C#N)O
InChI	1S/C17H11NO2/c18-10-14-8-16(20)7-13-5-4-12(9-17(13)14)11-2-1-3-15(19)6-11/h1-9,19-20H
InChIKey	PBXARVUJEROSCH-UHFFFAOYSA-N
PubChem Compound ID	24950552
Target and Pathway
Target(s)	Estradiol 17 beta-dehydrogenase 1	Target Info	Inhibitor	[529595]
BioCyc Pathway	Superpathway of steroid hormone biosynthesis
	Estradiol biosynthesis I
KEGG Pathway	Steroid hormone biosynthesis
	Metabolic pathways
	Ovarian steroidogenesis
NetPath Pathway	FSH Signaling Pathway
PANTHER Pathway	Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway	Androgen and Estrogen Metabolism
Reactome	The canonical retinoid cycle in rods (twilight vision)
WikiPathways	Steroid Biosynthesis
	Metabolism of steroid hormones and vitamin D
	Prostate Cancer
References
Ref 529595	J Med Chem. 2008 Aug 14;51(15):4685-98. Epub 2008 Jul 17.Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design, synthesis, biological evaluation, and pharmacokinetics.
Ref 529595	J Med Chem. 2008 Aug 14;51(15):4685-98. Epub 2008 Jul 17.Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design, synthesis, biological evaluation, and pharmacokinetics.

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