Drug Information

Drug General Information
Drug ID
D0T2XU
Former ID
DAP000334
Drug Name
Promethazine
Synonyms
Antiallersin; Aprobit; Avomine; Camergan; Dimapp; Diphergan; Diprazin; Diprazine; Diprozin; Fargan; Fenazil; Fenetazina; Fenetazine; Genphen; Hiberna; Histargan; Iergigan; Isophenergan; Isopromethazine; Lercigan; Lergigan; Metaryl; Pelpica; Phargan; Phenargan; Phenerzine; Phensedyl; Pilothia; Pilpophen; Pipolphene; Proazaimine; Proazamine; Procit; Promacot; Promazinamide; Promergan; Promesan; Prometasin; Prometazin; Prometazina; Prometazine; Prometh; Promethacon; Promethaine; Promethazin; PromethazineHcl; Promethazinum; Promethegan; Promethiazine; Promezathine; Prorex; Protazine; Prothazin; Prothazine; Provigan; Pyrethia; Pyrethiazine; Remsed; Romergan; Rumergan; Tanidil; Thiergan; Valergine; Vallergine; Lilly 01516; Lilly 1516; RP 3277; SKF 1498; WY 509; A-91033; Atosil (TN); Avomine (TN); Fargan (TN); Farganesse (TN); Lergigan (TN); Phenergan (TN); Phenoject-50; Pro-50; Prometazina [INN-Spanish]; Promethazine [INN:BAN]; Promethazinum [INN-Latin]; Promethegan (TN); Prothiazine (TN); Receptozine (TN); Romergan (TN); Zipan-25; Dimethylamino-isopropyl-phenthiazin; Dimethylamino-isopropyl-phenthiazin [German]; Promethazine (JAN/INN); N-Dimethylamino-2-methylethyl thiodiphenylamine; PROMETHAZINE (SEE ALSO PROMETHAZINE HYDROCHLORIDE 58-33-3); N,N,alpha-Trimethyl-10H-phenothiazine-10-ethanamine; N-(2'-Dimethylamino-2'-methyl)ethylphenothiazine; N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine; N,N-dimethyl-1-phenothiazin-10-ylpropan-2-amine hydrochloride; N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine; (2-Dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine; (Dimethylamino-2-propyl-10-phenothiazine hydrochloride; 10-(2-(Dimethylamino)-2-methylethyl)phenothiazine; 10-(2-(Dimethylamino)propyl)phenothiazine; 10-(2-Dimethylaminopropyl)phenothiazine; 10-[2-(Dimethylamino)propyl]phenothiazine; 10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl-(9CI); 10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl-, radical ion(1+); 3389 R.p.
Drug Type
Small molecular drug
Indication Allergic disorders; Itching; Nausea [ICD9: 698, 787, 787.0, 995.3; ICD10:L29, R11, T78.4] Approved [538374], [542302]
Therapeutic Class
Antiallergic Agents
Company
Wyeth Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C17H20N2S
InChI
InChI=1S/C17H20N2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3
InChIKey
PWWVAXIEGOYWEE-UHFFFAOYSA-N
CAS Number
CAS 60-87-7
PubChem Compound ID
4927
PubChem Substance ID
9608, 89596, 616468, 5236627, 7847560, 7980398, 8153034, 10529464, 11335180, 11360419, 11363762, 11366324, 11368886, 11372096, 11374835, 11377048, 11406271, 11461391, 11466916, 11468036, 11484535, 11486631, 11488656, 11490834, 11492963, 11494682, 14848899, 24434790, 26752304, 29224005, 46507798, 47216602, 47216603, 47216604, 47290955, 47588815, 47885231, 48110274, 48184815, 48259042, 48416477, 49698886, 49854482, 50105224, 56313067, 56313700, 56459433, 57322528, 75806049, 85088938
ChEBI ID
ChEBI:8461
SuperDrug ATC ID
D04AA10; R06AD02
SuperDrug CAS ID
cas=000060877
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [536700], [537884]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538374FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 089013.
Ref 542302(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7282).
Ref 536700Intact cell binding for in vitro prediction of sedative and non-sedative histamine H1-receptor antagonists based on receptor internalization. J Pharmacol Sci. 2008 May;107(1):66-79. Epub 2008 Apr 29.
Ref 537884Inhibition by histamine H1 receptor antagonists of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes. Eur J Pharmacol. 1994 Jan 1;266(1):99-102.

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