| Drug General Information |
| Drug ID |
D00EOP
|
| Former ID |
DIB018756
|
| Drug Name |
AD-5061
|
| Synonyms |
AD-7057; AD7057; AD 7057; AD5061; AD 5061
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C22H20N2O4S
|
| InChI |
InChI=1S/C22H20N2O4S/c1-14-18(23-21(28-14)16-5-3-2-4-6-16)11-12-27-17-9-7-15(8-10-17)13-19-20(25)24-22(26)29-19/h2-10,19H,11-13H2,1H3,(H,24,25,26)
|
| InChIKey |
GUTCYOKMCPFRGH-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
|
| Target and Pathway |
| Target(s) |
Peroxisome proliferator activated receptor alpha |
Target Info |
Agonist |
[2]
|
|---|
| mRNA of PPAR-gamma |
Target Info |
Agonist |
[2]
|
|
KEGG Pathway
|
PPAR signaling pathway
|
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cAMP signaling pathway
|
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Adipocytokine signaling pathway
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Glucagon signaling pathway
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Non-alcoholic fatty liver disease (NAFLD)
|
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Hepatitis Chsa03320:PPAR signaling pathway
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AMPK signaling pathway
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Osteoclast differentiation
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Huntington's disease
|
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Pathways in cancer
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Transcriptional misregulation in cancer
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Thyroid cancer
|
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NetPath Pathway
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IL1 Signaling Pathway
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TGF_beta_Receptor Signaling Pathway
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Leptin Signaling Pathway
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PANTHER Pathway
|
CCKR signaling map ST
|
|
Pathway Interaction Database
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RXR and RAR heterodimerization with other nuclear receptorwnt_noncanonical_pathway:Noncanonical Wnt signaling pathway
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Calcineurin-regulated NFAT-dependent transcription in lymphocytes
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Signaling events mediated by HDAC Class I
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RXR and RAR heterodimerization with other nuclear receptor
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Regulation of retinoblastoma protein
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Reactome
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RORA activates gene expression
|
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BMAL1:CLOCK,NPAS2 activates circadian gene expression
|
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PPARA activates gene expression
|
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YAP1- and WWTR1 (TAZ)-stimulated gene expression
|
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Transcriptional activation of mitochondrial biogenesis
|
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Activation of gene expression by SREBF (SREBP)
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Transcriptional regulation of white adipocyte differentiation
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Nuclear Receptor transcription pathway
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Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
|
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Circadian ClockR-HSA-1989781:PPARA activates gene expression
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WikiPathways
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Nuclear Receptors in Lipid Metabolism and Toxicity
|
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Nuclear Receptors Meta-Pathway
|
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Estrogen Receptor Pathway
|
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PPAR Alpha Pathway
|
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Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
|
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Transcriptional Regulation of White Adipocyte Differentiation
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YAP1- and WWTR1 (TAZ)-stimulated gene expression
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Activation of Gene Expression by SREBP (SREBF)
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Adipogenesis
|
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SREBF and miR33 in cholesterol and lipid homeostasis
|
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Circadian Clock
|
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Nuclear ReceptorsWP363:Wnt Signaling Pathway Netpath
|
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Differentiation of white and brown adipocyte
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SREBP signalling
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Nuclear Receptors
|
| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2663). |
|---|
| REF 2 | A novel oxyiminoalkanoic acid derivative, TAK-559, activates human peroxisome proliferator-activated receptor subtypes. Eur J Pharmacol. 2004 Jul 8;495(1):17-26. |
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