Drug General Information
Drug ID
D02CIT
Former ID
DIB019808
Drug Name
EI1
Synonyms
KB-145943
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532154]
Structure
Download
2D MOL
Formula
C23H26N4O2
InChI
InChI=1S/C23H26N4O2/c1-5-17(6-2)27-8-7-18-19(10-16(12-24)11-21(18)27)22(28)25-13-20-14(3)9-15(4)26-23(20)29/h7-11,17H,5-6,13H2,1-4H3,(H,25,28)(H,26,29)
InChIKey
PFHDWRIVDDIFRP-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Enhancer of zeste homolog 2 Target Info Inhibitor [532154]
KEGG Pathway MicroRNAs in cancer
NetPath Pathway IL2 Signaling Pathway
Reactome PRC2 methylates histones and DNA
Oxidative Stress Induced Senescence
PKMTs methylate histone lysines
WikiPathways Interactome of polycomb repressive complex 2 (PRC2)
Endoderm Differentiation
Integrated Pancreatic Cancer Pathway
Histone Modifications
Cell Differentiation - meta
miRs in Muscle Cell Differentiation
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
References
Ref 532154Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21360-5.
Ref 532154Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21360-5.

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