Drug General Information
Drug ID	D0D7PF
Former ID	DNC011286
Drug Name	3-((2-Pyrrolidine-1-yl)-ethyl)uracil
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[531149]
Structure		Download 2D MOL 3D MOL
Formula	C10H15N3O2
Canonical SMILES	C1CCN(C1)CCN2C(=O)C=CNC2=O
InChI	1S/C10H15N3O2/c14-9-3-4-11-10(15)13(9)8-7-12-5-1-2-6-12/h3-4H,1-2,5-8H2,(H,11,15)
InChIKey	XKWFMZHWDROEIH-UHFFFAOYSA-N
PubChem Compound ID	49845542
Target and Pathway
Target(s)	Purine nucleoside phosphorylase	Target Info	Inhibitor	[531149]
BioCyc Pathway	Arsenate detoxification I (glutaredoxin)
	Purine nucleotides degradation
	Urate biosynthesis/inosine 5'-phosphate degradation
	Purine deoxyribonucleosides degradation
	Purine ribonucleosides degradation to ribose-1-phosphate
	Guanosine nucleotides degradation
	Adenosine nucleotides degradation
	Superpathway of purine nucleotide salvage
	Adenine and adenosine salvage III
	Guanine and guanosine salvage
KEGG Pathway	Purine metabolism
	Pyrimidine metabolism
	Nicotinate and nicotinamide metabolism
	Metabolic pathways
NetPath Pathway	TCR Signaling Pathway
	EGFR1 Signaling Pathway
PANTHER Pathway	Adenine and hypoxanthine salvage pathway
	Xanthine and guanine salvage pathway
PathWhiz Pathway	Purine Metabolism
	Nicotinate and Nicotinamide Metabolism
Reactome	Purine salvage
	Purine catabolism
WikiPathways	miR-targeted genes in squamous cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in leukocytes - TarBase
	miR-targeted genes in epithelium - TarBase
	Metabolism of nucleotides
References
Ref 531149	Eur J Med Chem. 2010 Nov;45(11):5140-9. Epub 2010 Aug 14.Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase.
Ref 531149	Eur J Med Chem. 2010 Nov;45(11):5140-9. Epub 2010 Aug 14.Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase.

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