Drug Information

Drug General Information
Drug ID
D0X5DB
Former ID
DNC010836
Drug Name
4-(2-(4-tert-Butylphenylamino)ethyl)-1H-imidazole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530846]
Structure
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2D MOL

3D MOL
Formula
C15H21N3
Canonical SMILES
CC(C)(C)C1=CC=C(C=C1)NCCC2=CN=CN2
InChI
1S/C15H21N3/c1-15(2,3)12-4-6-13(7-5-12)17-9-8-14-10-16-11-18-14/h4-7,10-11,17H,8-9H2,1-3H3,(H,16,18)
InChIKey
CAUIWLDBMLQRJD-UHFFFAOYSA-N
PubChem Compound ID
46222045
Target and Pathway
Target(s) Histamine H3 receptor Target Info Inhibitor [530846]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 530846J Med Chem. 2010 May 13;53(9):3840-4.Role of hydrophobic substituents on the terminal nitrogen of histamine in receptor binding and agonist activity: development of an orally active histamine type 3 receptor agonist and evaluation of its antistress activity in mice.
Ref 530846J Med Chem. 2010 May 13;53(9):3840-4.Role of hydrophobic substituents on the terminal nitrogen of histamine in receptor binding and agonist activity: development of an orally active histamine type 3 receptor agonist and evaluation of its antistress activity in mice.

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