Drug General Information
Drug ID	D0AK9X
Former ID	DNC014693
Drug Name	4-Amino-3-(5-chloro-thiophen-2-yl)-butyric acid
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528071]
Structure		Download 2D MOL 3D MOL
Formula	C8H10ClNO2S
Canonical SMILES	C1=C(SC(=C1)Cl)C(CC(=O)O)CN
InChI	1S/C8H10ClNO2S/c9-7-2-1-6(13-7)5(4-10)3-8(11)12/h1-2,5H,3-4,10H2,(H,11,12)
InChIKey	CDFQDLUHBLZCGL-UHFFFAOYSA-N
PubChem Compound ID	125917
Target and Pathway
Target(s)	Gamma-aminobutyric acid B receptor	Target Info	Inhibitor	[528071]
KEGG Pathway	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	GABAergic synapse
	Estrogen signaling pathway
	Morphine addiction
Reactome	Activation of G protein gated Potassium channels
	G alpha (i) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
WikiPathways	GPCRs, Class C Metabotropic glutamate, pheromone
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Potassium Channels
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 528071	J Med Chem. 1991 Aug;34(8):2557-60.3-Thienyl- and 3-furylaminobutyric acids. Synthesis and binding GABAB receptor studies.
Ref 528071	J Med Chem. 1991 Aug;34(8):2557-60.3-Thienyl- and 3-furylaminobutyric acids. Synthesis and binding GABAB receptor studies.

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