Drug Information

Drug General Information
Drug ID
D0V3IT
Former ID
DNC004177
Drug Name
SNAP-5150
Drug Type
Small molecular drug
Indication Discovery agent Investigative [525611]
Structure
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2D MOL

3D MOL
Formula
C36H41N5O4
Canonical SMILES
CC1=C(C(C(=C(N1)C)C(=O)NCCCCN2CCC(CC2)(C3=CC=CC=C3)C4=C<br />C=CC=C4)C5=CC=C(C=C5)[N+](=O)[O-])C(=O)N
InChI
1S/C36H41N5O4/c1-25-31(34(37)42)33(27-15-17-30(18-16-27)41(44)45)32(26(2)39-25)35(43)38-21-9-10-22-40-23-19-36(20-24-40,28-11-5-3-6-12-28)29-13-7-4-8-14-29/h3-8,11-18,33,39H,9-10,19-24H2,1-2H3,(H2,37,42)(H,38,43)/t33-/m0/s1
InChIKey
RJEWWPFKTYWTSS-XIFFEERXSA-N
PubChem Compound ID
44390749
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Inhibitor [525611]
Alpha-2B adrenergic receptor Target Info Inhibitor [525611]
Alpha-2A adrenergic receptor Target Info Inhibitor [525611]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolismR-HSA-390696:Adrenoceptors
G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
GPCR downstream signaling
References
Ref 525611Bioorg Med Chem Lett. 1999 Oct 4;9(19):2843-8.Design and synthesis of novel dihydropyridine alpha-1a antagonists.
Ref 525611Bioorg Med Chem Lett. 1999 Oct 4;9(19):2843-8.Design and synthesis of novel dihydropyridine alpha-1a antagonists.

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