Drug General Information
Drug ID
D0SL8T
Former ID
DPR000177
Drug Name
ISIS-FGFR4
Drug Type
Antisense drug
Indication Obesity [ICD9: 278; ICD10:E66] Preclinical [551052]
Company
ISIS Pharm
Target and Pathway
Target(s) mRNA of FGFR4 Target Info [551052]
KEGG Pathway MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Signaling pathways regulating pluripotency of stem cells
Regulation of actin cytoskeleton
PANTHER Pathway FGF signaling pathway
Pathway Interaction Database FGF signaling pathway
Reactome PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
Constitutive Signaling by Aberrant PI3K in Cancer
Phospholipase C-mediated cascade
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR4 signaling
RAF/MAP kinase cascade
WikiPathways Regulation of Actin Cytoskeleton
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
PIP3 activates AKT signaling
Signaling by FGFR
References
Ref 551052Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).
Ref 551052Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).

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